Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C44H58N8O5S |
| Molecular Weight | 811.047 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
| Stereo Comments | AXIAL, R |
SHOW SMILES / InChI
SMILES
CCN1C2=C3C=C(C=C2)C4=CSC(C[C@H](NC(=O)[C@H]5C[C@@H]5C)C(=O)N6CCC[C@H](N6)C(=O)OCC(C)(C)CC3=C1C7=CC(=CN=C7[C@H](C)OC)N8CCN(C)CC8)=N4
InChI
InChIKey=FVICRBSEYSHKFY-JYQNNKODSA-N
InChI=1S/C44H58N8O5S/c1-8-51-37-12-11-28-19-31(37)33(40(51)32-20-29(23-45-39(32)27(3)56-7)50-16-14-49(6)15-17-50)22-44(4,5)25-57-43(55)34-10-9-13-52(48-34)42(54)35(21-38-46-36(28)24-58-38)47-41(53)30-18-26(30)2/h11-12,19-20,23-24,26-27,30,34-35,48H,8-10,13-18,21-22,25H2,1-7H3,(H,47,53)/t26-,27-,30-,34-,35-/m0/s1
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
503.7 nM |
400 mg 1 times / day steady-state, oral dose: 400 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
RMC-6236 blood | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
7131 nM × h |
400 mg 1 times / day steady-state, oral dose: 400 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
RMC-6236 blood | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
8.1 h |
400 mg 1 times / day steady-state, oral dose: 400 mg route of administration: Oral experiment type: STEADY-STATE co-administered: |
RMC-6236 blood | Homo sapiens population: UNHEALTHY age: ADULT sex: FEMALE / MALE food status: UNKNOWN |
Funbound
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
2.3% EXPERIMENT https://pubmed.ncbi.nlm.nih.gov/38593348/ |
unknown |
RMC-6236 plasma | Homo sapiens population: UNKNOWN age: UNKNOWN sex: UNKNOWN food status: UNKNOWN |
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Preferred Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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13270
Created by
admin on Wed Apr 02 10:30:03 GMT 2025 , Edited by admin on Wed Apr 02 10:30:03 GMT 2025
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PRIMARY | |||
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B6T47Y2UAP
Created by
admin on Wed Apr 02 10:30:03 GMT 2025 , Edited by admin on Wed Apr 02 10:30:03 GMT 2025
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PRIMARY | |||
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2765081-21-6
Created by
admin on Wed Apr 02 10:30:03 GMT 2025 , Edited by admin on Wed Apr 02 10:30:03 GMT 2025
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PRIMARY | |||
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164726578
Created by
admin on Wed Apr 02 10:30:03 GMT 2025 , Edited by admin on Wed Apr 02 10:30:03 GMT 2025
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PRIMARY |
ACTIVE MOIETY
