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Restrict the search for
methylprednisolone succinate
to a specific field?
Status:
Possibly Marketed Outside US
Source:
21 CFR 333E
(1989)
Source URL:
First approved in 1980
Source:
NADA113232
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Monoethanolamine is both a primary amine and a primary alcohol. It is an olamine derivative. Monoethanolamine occurs in every cell in the human body as the head group of Phosphatidylethanolamine. Monoethanolamine is a component of glycosylphosphatidylinositol-anchored proteins, which are essential for viability. Other sources of monoethanolamine or phosphoethanolamine in the human body are the degradation of sphingosine phosphate by sphingosine phosphate lyase and the degradation of the endocannabinoid anandamide by the fatty acid amine hydrolase. Monoethanolamine stimulates the rapid growth of mammalian cells in culture. Monoethanolamine has a cardioprotective role against ischemia/reperfusion injury via activation of the transcription factor STAT-3. Monoethanolamine is a chemical intermediate in the manufacture of cosmetics, surface-active agents, emulsifiers, pharmaceuticals, and plasticizing agents.
Status:
Possibly Marketed Outside US
Source:
VASCULAT by Boehringer Ingelheim
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Bamethan (butyl-sympatol or vasculat) is an adrenaline derivative developed by C. H. Boehringer Sohn. Bamethan shows a depressor action on peripheral blood vessels as a result of the peripheral vasodilating action caused by stimulation of adrenergic beta-receptor. Bamethan has been used abroad in the treatment of certain peripheral vascular and circulatory disturbances, such as vasospastic conditions, arteriosclerotic peripheral vascular disease, Raynaud's syndrome, occlusive vascular disease of the legs, the post-thrombotic syndrome, degenerative muscular disorders, and other conditions involving peripheral vascular insuffciency.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Siccanin is an unusual, fused, phenolic pentacycle first isolated from Helminthosporium siccans and reported in 1962 as a potent antifungal agent. Siccanin inhibits succinate dehydrogenase in the terminal electron transport system. More recent studies note the proximity of the siccanin binding site to the quinone-binding site of the enzyme. Species-selective inhibition by siccanin is unique among succinate dehydrogenase inhibitors and offers a lead for new chemotherapeutics.
Status:
Possibly Marketed Outside US
Source:
NCT00371826: Phase 4 Interventional Completed Renal Transplanted Recipients
(2006)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
11-keto methylprednisolone is a metabolite of corticosteroid immunosuppressant methylprednisolone.
Status:
Possibly Marketed Outside US
Source:
Unknown by Ginoulhiac, E.|Semenza, F.
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Dextramycin ((S, S)-p-Chloramphenicol) is an optical isomer of Chloramphenicol, a broad-spectrum antibiotic with historical veterinary use in all major food-producing animals. The drug is biosynthesized by the soil organism Streptomyces venezuelae and several other actinomycetes and is chemically synthesized for commercial use. Chloramphenicol occurs in the meta-configuration and in the para-configuration and it contains two chiral centers thus in total eight different isomeric configurations exist. All para-stereoisomers are biologically active and 0.5% solution of Dextramycin shows antimicrobial activity. Currently, Chloramphenicol has banned for use in all food-producing animals.
Status:
Possibly Marketed Outside US
Source:
Indenolol by Yamanouchi Pharmaceutical
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
3-ISOPROPYLAMINO-1,2-PROPANEDIOL (Indenolol) is an antihypertensive agent, whose beta 1-adrenoceptor antagonist properties combined with beta 2-adrenoceptor agonist properties have been shown by experimental studies in animals. It was used for the treatment of angina pectoris, hypertension, arrhythmias
Status:
Possibly Marketed Outside US
Source:
NCT03231709: Phase 4 Interventional Completed Type 2 Diabetes Mellitus
(2017)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Trelagliptin (SYR-472), a novel dipeptidyl peptidase-4 inhibitor used for the treatment of type 2 diabetes mellitus. Trelagliptin (as the salt Trelagliptin succinate) was approved for use in Japan in March 2015. Takeda, the company that developed Trelagliptin, chose to not get approval for the drug in the USA and EU.
Status:
Possibly Marketed Outside US
Source:
NCT00567983: Phase 4 Interventional Completed Disease Progression
(2007)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Boscalid is a new pesticide belonging to the class of oxathiin fungicides, also known as
carboxamide, carboxin or (carbox) anilide fungicides. U.S. EPA has designated the proposed
uses of boscalid as “reduced risk.” Boscalid works by inhibiting mitrochondial respiration and
subsequent production of ATP in fungal cells. Boscalid has a new mode of action and is
effective against pathogens resistant to other fungicides, including those resistant to sterol
inhibitors, dicarboximides, benzimidazoles, anilinopyrimidines, phenylamides and strobilurins.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Dibutyl succinate is used as an insecticide, surfactant and insect attractant. Preliminary investigations have found that dibutyl succinate exhibits insulinotropic action on isolated islet cells suggesting that it may have some application for the treatment of diabetes.
Status:
Possibly Marketed Outside US
Source:
NCT00540787: Phase 4 Interventional Completed Paroxysmal Atrial Fibrillation
(2003)
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Cibenzoline is a class I sodium channel blocker
antiarrhythmic drug available in a limited number
of countries. Cibenzoline also has moderate calcium channel blocking (class IV) effects and prolongs the action potential duration through its potassium channel blocking (class III) effect. It is used for the treatment of supraventricular and ventricular arrhythmias, and in obstructive hypertrophic cardiomyopathy.
