U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 2821 - 2830 of 3083 results

Status:
US Approved Allergenic Extract (1994)

Class (Stereo):
CHEMICAL (ACHIRAL)

N-isopropyl-N'-phenylparaphenylenediamine (IPPD), an amine antiozonant, is used in rubber manufacture and is a human allergen.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(20) weight control sodium
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Sodium hydride is the chemical compound produced by the reaction of metallic sodium with hydrogen gas. It is a flammable solid and reacts violently with water in any form, liberating hydrogen. Sodium hydride is widely used in organic chemistry to deprotonate alcohols, amine, amides, and other sufficiently acidic protons. Sodium hydride is also used as a reducing agent and is effective for removing the last traces of water, alcohols, oxygen, and some sulfur compounds from solvents and certain gases.
Biperiden, sold under the brandname Akineton was used as an adjunct in the therapy of all forms of parkinsonism (postencephalitic, arteriosclerotic and idiopathic). Was also useful in the control of extrapyramidal disorders due to central nervous system drugs such as phenothiazines and other groups of psychotropics. Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as biperiden is considered to relate to competitive antagonism of acetylcholine at cholinergic receptors in the corpus striatum, which then restores the balance. Atropine-like side effects such as dry mouth; blurred vision; drowsiness; euphoria or disorientation; urinary retention; postural hypotension; constipation; agitation; disturbed behavior may been seen. Only limited pharmacokinetic studies of biperiden in humans are available.
Status:
US Previously Marketed
Source:
PHENY-PAS-TEBAMIN by PHARM RES ASSOC
(1961)
Source URL:
First approved in 1959
Source:
Pheny-PAS-Tebamin by Purdue Frederick
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Phenyl Aminosalicylate is the phenyl ester of para-aminosalicylic acid, reported to have less side effects than simple salts of para-aminosalicylic acid. It’s a second-line antituberculosis drug with a high incidence of hypersensitivity reactions and gastrointestinal upset.
Status:
US Previously Marketed
First approved in 1955

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Potassium Aminosalicylate is the potassium salt form of aminosalicylic acid, an analog of aminobenzoic acid used to treat tuberculosis. There are two mechanisms responsible for aminosalicylic acid's bacteriostatic action against Mycobacterium tuberculosis. Firstly, aminosalicylic acid inhibits folic acid synthesis (without potentiation with antifolic compounds). The binding of para-aminobenzoic acid to pteridine synthetase acts as the first step in the folic acid synthesis. Aminosalicylic acid binds pteridine synthetase with greater affinity than para-aminobenzoic acid, effectively inhibiting the synthesis of folic acid. As bacteria are unable to use external sources of folic acid, cell growth and multiplication slow. Secondly, aminosalicylic acid may inhibit the synthesis of the cell wall component, mycobactin, thus reducing iron uptake by M. tuberculosis. Specifically, Potassium Aminosalicylate is used to treat active drug-resistant tuberculosis together with other antituberculosis medications. Potassium Aminosalicylate t has also been used as a second line agent to sulfasalazine in people with inflammatory bowel disease such as ulcerative colitis and Crohn's disease.

Showing 2821 - 2830 of 3083 results