N-ISOPROPYL-N'-PHENYL-1,4-PHENYLENEDIAMINE

US Approved Allergenic Extract (1994)

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H18N2
Molecular Weight	226.3168
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of N-ISOPROPYL-N'-PHENYL-1,4-PHENYLENEDIAMINE

Structure Search

SMILES

CC(C)NC1=CC=C(NC2=CC=CC=C2)C=C1

InChI

InChIKey=OUBMGJOQLXMSNT-UHFFFAOYSA-N

InChI=1S/C15H18N2/c1-12(2)16-14-8-10-15(11-9-14)17-13-6-4-3-5-7-13/h3-12,16-17H,1-2H3

HIDE SMILES / InChI

Molecular Formula	C15H18N2
Molecular Weight	226.3168
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/139282 | https://www.ncbi.nlm.nih.gov/pubmed/6450039

N-isopropyl-N'-phenylparaphenylenediamine (IPPD), an amine antiozonant, is used in rubber manufacture and is a human allergen.

Approval Year

PubMed

Title	Date	PubMed
Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.	2015-05	25622337
Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity.	2013-06	22954530
Contact sensitization in very young children.	2011-10	21616561
Skin sensitization potency and cross-reactivity of p-phenylenediamine and its derivatives evaluated by non-radioactive murine local lymph node assay and guinea-pig maximization test.	2009-04	19338586
[Evidence-based evaluation of the effect of Type IV Allergies on the reduction of fitness for work. Survey of occupational skin diseases].	2005-03	15678349
Patch testing with the irritant sodium lauryl sulfate (SLS) is useful in interpreting weak reactions to contact allergens as allergic or irritant.	2003-02	12694214
Occupational relevance of positive standard patch-test results in employed persons with an initial report of an occupational skin disease.	2002-08	12070639

Patents

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:50:24 GMT 2025` Edited by `admin` on `Mon Mar 31 18:50:24 GMT 2025`
Record UNII	0M7PSL4100
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

N-ISOPROPYL-N'-PHENYL-1,4-PHENYLENEDIAMINE

Systematic Name

English

N-ISOPROPYL-N'-PHENYL-4-PHENYLENEDIAMINE

Preferred Name

English

1,4-BENZENEDIAMINE, N-(1-METHYLETHYL)-N'-PHENYL-

Systematic Name

English

N-ISOPROPYL-N'-PHENYL-PARA-PHENYLENEDIAMINE

Systematic Name

English

N-ISOPROPYL-N'-PHENYL PARAPHENYLENEDIAMINE

Systematic Name

English

N-ISOPROPYL-N'-PHENYL-P-PHENYLENEDIAMINE

Common Name

English

IPPD

Common Name

English

NSC-41029

Code

English

4-(ISOPROPYLAMINO)DIPHENYLAMINE [HSDB]

Common Name

English

Classification Tree Code System Code

NDF-RT

N0000185508