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Details

Stereochemistry ACHIRAL
Molecular Formula C7H6NO3.K
Molecular Weight 191.2257
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of POTASSIUM AMINOSALICYLATE

SMILES

[K+].NC1=CC(O)=C(C=C1)C([O-])=O

InChI

InChIKey=PRZJIMSXCLZGLT-UHFFFAOYSA-M
InChI=1S/C7H7NO3.K/c8-4-1-2-5(7(10)11)6(9)3-4;/h1-3,9H,8H2,(H,10,11);/q;+1/p-1

HIDE SMILES / InChI

Molecular Formula K
Molecular Weight 39.0983
Charge 1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C7H6NO3
Molecular Weight 152.1274
Charge -1
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Potassium Aminosalicylate is the potassium salt form of aminosalicylic acid, an analog of aminobenzoic acid used to treat tuberculosis. There are two mechanisms responsible for aminosalicylic acid's bacteriostatic action against Mycobacterium tuberculosis. Firstly, aminosalicylic acid inhibits folic acid synthesis (without potentiation with antifolic compounds). The binding of para-aminobenzoic acid to pteridine synthetase acts as the first step in the folic acid synthesis. Aminosalicylic acid binds pteridine synthetase with greater affinity than para-aminobenzoic acid, effectively inhibiting the synthesis of folic acid. As bacteria are unable to use external sources of folic acid, cell growth and multiplication slow. Secondly, aminosalicylic acid may inhibit the synthesis of the cell wall component, mycobactin, thus reducing iron uptake by M. tuberculosis. Specifically, Potassium Aminosalicylate is used to treat active drug-resistant tuberculosis together with other antituberculosis medications. Potassium Aminosalicylate t has also been used as a second line agent to sulfasalazine in people with inflammatory bowel disease such as ulcerative colitis and Crohn's disease.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
PASKALIUM

Approved Use

Paskalium is indicated for the treatment of tuberculosis in combination with other active agents. It is most commonly used in patients with Multi-drug Resistant TB (MDR-TB) or in situations when therapy with isoniazid and rifampin is not possible due to a combination of resistance and/or intolerance. When Paskalium is added to the treatment regimen in patients proven or suspected drug resistance, it should be accompanied by at least one and preferably two other new agents to which the patient's organism is known or expected to be susceptible.

Launch Date

1955
Overview

Overview

CYP3A4CYP2C9CYP2D6hERG

Drug as perpetrator​Drug as victim
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:17:09 GMT 2023
Edited
by admin
on Fri Dec 15 15:17:09 GMT 2023
Record UNII
7N21461LKD
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
POTASSIUM AMINOSALICYLATE
ORANGE BOOK  
Systematic Name English
BENZOIC ACID, 4-AMINO-2-HYDROXY-, POTASSIUM SALT (1:1)
Common Name English
PASKALIUM
Brand Name English
P-AMINOSALICYLIC ACID POTASSIUM SALT
MI  
Common Name English
POTASSIUM AMINOSALICYLATE [ORANGE BOOK]
Common Name English
Monopotassium 4-aminosalicylate
Systematic Name English
AMINOSALICYLATE POTASSIUM
Systematic Name English
P-AMINOSALICYLIC ACID POTASSIUM SALT [MI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C280
Created by admin on Fri Dec 15 15:17:09 GMT 2023 , Edited by admin on Fri Dec 15 15:17:09 GMT 2023
Code System Code Type Description
DRUG BANK
DBSALT002415
Created by admin on Fri Dec 15 15:17:09 GMT 2023 , Edited by admin on Fri Dec 15 15:17:09 GMT 2023
PRIMARY
FDA UNII
7N21461LKD
Created by admin on Fri Dec 15 15:17:09 GMT 2023 , Edited by admin on Fri Dec 15 15:17:09 GMT 2023
PRIMARY
ChEMBL
CHEMBL1169
Created by admin on Fri Dec 15 15:17:09 GMT 2023 , Edited by admin on Fri Dec 15 15:17:09 GMT 2023
PRIMARY
NCI_THESAURUS
C47678
Created by admin on Fri Dec 15 15:17:09 GMT 2023 , Edited by admin on Fri Dec 15 15:17:09 GMT 2023
PRIMARY
MERCK INDEX
m1743
Created by admin on Fri Dec 15 15:17:09 GMT 2023 , Edited by admin on Fri Dec 15 15:17:09 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
205-090-7
Created by admin on Fri Dec 15 15:17:09 GMT 2023 , Edited by admin on Fri Dec 15 15:17:09 GMT 2023
PRIMARY
CAS
133-09-5
Created by admin on Fri Dec 15 15:17:09 GMT 2023 , Edited by admin on Fri Dec 15 15:17:09 GMT 2023
PRIMARY
EPA CompTox
DTXSID3059634
Created by admin on Fri Dec 15 15:17:09 GMT 2023 , Edited by admin on Fri Dec 15 15:17:09 GMT 2023
PRIMARY
PUBCHEM
23690428
Created by admin on Fri Dec 15 15:17:09 GMT 2023 , Edited by admin on Fri Dec 15 15:17:09 GMT 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE