U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 2701 - 2710 of 2893 results

Status:
US Previously Marketed
Source:
Ceepryn by Merrell
(1941)
Source URL:
First approved in 1941
Source:
Ceepryn by Merrell
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Cetylpyridinium (used in a form of chloride salt) is a cationic surface-active agent and has a broad antimicrobial spectrum, with rapid killing of gram-positive pathogens and yeast in particular. It is suggested that interaction with bacteria occurs by the disruption of membrane function, leakage of cytoplasmic material, and ultimately the collapse of the intra-cellular equilibrium. The drug is used under various trade names as an oral OTC hygiene product (mouthwash, dental kits, etc.) to control the dental plaque and to prevent the subsequent gingivitis.
Status:
US Previously Marketed
Source:
ALLANTOMIDE SULFANILAMIDE by NATIONAL DRUG
(1961)
Source URL:
First marketed in 1936
Source:
sulfanilamide
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Sulfanilamide is an anibiotic drug, which has been used for decades for the treatment of vulvovaginal candidiasis. The drug blocks folic acid synthesis in bacterias by inhibitin the enzyme dihydropteroate synthase.
Status:
US Previously Marketed
Source:
ACR-ALLANTOMIDE AMINACRINE HYDROCHLORIDE by NATIONAL DRUG
(1961)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Aminacrine has long been known to be a potent frameshift mutagen in viruses and bacteria. It is one in a general class of aminoacridine dyes that bind to DNA and possess mutagenic activity. Aminacrine is used clinically as a topical antiseptic. A part from therapeutic use, aminacrine is also introduced as a matrix for negative mode matrix-assisted laser desorption/ionization (MALDI).
Status:
US Previously Marketed
Source:
Dinitrophenol
(1933)
Source URL:
First marketed in 1933

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

2,4-dinitrophenol (DNP) is a FDA-banned weight-loss agent and EPA-regulated environmental toxicant, traditionally used in research labs as an uncoupler of OXPHOS. Although not licensed for human consumption, DNP and DNP crystal form are used by bodybuilders and extreme dieters for their fat burning properties through inhibiting efficient energy (ATP) production in cells. Through uncoupling mitochondrial oxidative phosphorylation by facilitating proton transport across the mitochondrial membrane, DNP leads to rapid consumption of energy without generating ATP and consequently, to increased fat metabolism. However, the weight-loss effect comes with serious, and in some cases potentially fatal, adverse side effects, namely hyperthermia (the leading cause of fatality with acute DNP toxicity) and cardiac arrest, but also diaphoresis, tachycardia, tachypnea, skin toxicity, Fourier’s gangrene and cataracts with low dose chronic exposure. The proposed mechanism of DNP induced toxicity suggests the activation of ATP-sensitive K channels.
Status:
US Previously Marketed
Source:
Chlorinated Lime U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Chlorinated Lime U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

CALCIUM CHLORIDE HYDROXIDE HYPOCHLORITE, DIHYDRATE is an inert ingredient in pesticide products.
Status:
US Previously Marketed
Source:
GENTIA-JEL APPLICATORS by WESTWOOD
(1961)
Source URL:
First marketed in 1921
Source:
gentian violet
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Gentian violet ((GV) hexamethyl pararosaniline, also known as crystal violet, methyl violet) is a triphenylmethane dye with anti-bacterial, anti-fungal, anti-helminithic, anti-trypanosomal, anti-angiogenic and anti-tumor properties. GV has a lengthy history and has been used successfully as monotherapy and an adjunct to treatment in a variety of diseases. Gentian violet interacts with negatively charged components of bacterial cells including the lipopolysaccharide (on the cell wall), the peptidoglycan and DNA. A similar cell penetration and DNA binding process is thought to take place for fungal cells as well. Because Gentian violet is a mutagen and mitotic poison, cell growth is consequently inhibited. A photodynamic action of gentian violet, apparently mediated by a free-radical mechanism, has recently been described in bacteria and in the protozoan T. cruzi. Evidence also suggests that gentian violet dissipates the bacterial (and mitochondrial) membrane potential by inducing permeability. This is followed by respiratory inhibition. This anti-mitochondrial activity might explain gentian violet's efficacy towards both bacteria and yeast with relatively mild effects on mammalian cells.
Status:
US Previously Marketed
Source:
Sodium Perborate U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Sodium Perborate U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Sodium perborate monohydrate is an inorganic sodium salt widely used in laundry detergents and in peroxide-based bleaches, such as tooth whitening products. It also has antiseptic and disinfectant properties and is therefore used as an oral debriding agent or oral wound cleanser.
Status:
US Previously Marketed
Source:
NYLMERATE BORIC ACID by HOLLAND-RANTDS
(1961)
Source URL:
First marketed in 1921
Source:
Boric Acid U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

AMMONIUM BORATE is used in fireproofing wood and textiles, and also in electrolytic condensers. It can be indirect additive used in food contact substances.

Showing 2701 - 2710 of 2893 results