DISODIUM OCTABORATE

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	B8O13.2Na
Molecular Weight	340.46
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].[O-]B1OB(OB=O)OB2OB([O-])OB(OB=O)OB(O1)O2

InChI

InChIKey=UMJBSWIMVVXGOU-UHFFFAOYSA-N

InChI=1S/B8O13.2Na/c9-1-13-5-15-3(11)17-8-20-6(14-2-10)16-4(12)18-7(19-5)21-8;;/q-2;2*+1

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	B8O13
Molecular Weight	294.48
Charge	-2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.accessdata.fda.gov/scripts/fdcc/index.cfm?set=IndirectAdditives&id=AMMONIUMBORATE | https://www.drugfuture.com/chemdata/ammonium-borate.html

AMMONIUM BORATE is used in fireproofing wood and textiles, and also in electrolytic condensers. It can be indirect additive used in food contact substances.

Approval Year

PubMed

Title	Date	PubMed
Endpoints of spermatotoxicity in the rat after short duration exposures to fourteen reproductive toxicants.	1992	1288759
Advances in understanding mechanisms of toxicity and implications for risk assessment.	1997 Mar-Jun	9100314
Boron modulates extracellular matrix and TNF alpha synthesis in human fibroblasts.	1998 May 29	9618283
Defects in cervical vertebrae in boric acid-exposed rat embryos are associated with anterior shifts of hox gene expression domains.	2003 Jan	12749385
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.	2006 Nov	16497524
Boric acid inhibits embryonic histone deacetylases: a suggested mechanism to explain boric acid-related teratogenicity.	2007 Apr 15	17320131
Boric acid inhibits LPS-induced TNF-alpha formation through a thiol-dependent mechanism in THP-1 cells.	2008	18755394
Experimental study on the estrogen-like effect of boric Acid.	2008 Feb	17943231
Inhibition profile of Leishmania mexicana arginase reveals differences with human arginase I.	2011 Apr	21232540
Boric acid increases the expression levels of human anion exchanger genes SLC4A2 and SLC4A3.	2012 Apr 3	22576912
Protective effect of boric acid against carbon tetrachloride-induced hepatotoxicity in mice.	2012 Jul	21999471
Assessment of developmental delay in the zebrafish embryo teratogenicity assay.	2013 Feb	22898132
Comparison of osteoblast and cardiomyocyte differentiation in the embryonic stem cell test for predicting embryotoxicity in vivo.	2014 Sep	24704097
The Effects of Boron on Arsenic-Induced Lipid Peroxidation and Antioxidant Status in Male and Female Rats.	2015 Dec	26184899

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:38:39 GMT 2023` Edited by `admin` on `Sat Dec 16 08:38:39 GMT 2023`
Record UNII	JT9XWY98MF
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DISODIUM OCTABORATE

Systematic Name

English

SODIUM BORATE (NA2B8O13)

Common Name

English

BORA-CARE

Brand Name

English

POLYBOR-150

Brand Name

English

POLYBOR

Brand Name

English

BORIC ACID (H2B8O13), DISODIUM SALT

Common Name

English

BORACOL-40

Brand Name

English

BORON SODIUM OXIDE (B8NA2O13)

Common Name

English

IMPEL

Brand Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

11107