U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 241 - 250 of 3580 results

Status:
Investigational
Source:
USAN:Acebrochol
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Acebrochol is a neuroactive steroid that may act as a sedative and hypnotic, through the mechanism of altering ligand-gated ion channels and cell surface receptors.
Status:
Investigational
Source:
INN:seglitide
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Seglitide (previously known as L363,586 or MK-678), a cyclic, hexapeptide analog of somatostatin-14, is a somatostatin receptor 2 (SSTR2) agonist. This compound was studied in Alzheimer's disease. Besides, it possessed inhibitory actions on rat growth hormone (GH) release and thus could have a role in the treatment of acromegaly. Intravenous and intranasal administration of seglitide to diabetic subjects was effective in reducing both fasting and postprandial hyperglycemia. Thus, this compound could be useful in the control of unstable diabetes. In addition, preclinical studies have shown that seglitide had potential as a treatment for diabetic retinopathy and macular degeneration. However, the further studied of this compound were discontinued.
Status:
Investigational
Source:
INN:rifamexil
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Rifamexil (also known as MDL 62769 or P/DEA) is a derivative of rifamycin (a natural antibiotic produced by Amycolatopsis rifamycinica). This drug has greater intrinsic activity against Myobacterium avium (MAC) than rifampin. Information on current use of this compound is not available.
Status:
Investigational
Source:
INN:nisbuterol
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Nisbuterol, a nicotinic acid ester, is a bronchodilator.
Status:
Investigational
Source:
INN:salmisteine
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Salmisteine was studied as an antipyretic and mucolytic agent. Information about the current use of this compound is not available.
Status:
Investigational
Source:
INN:oxabrexine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Oxabrexine was developed as a diuretic; however, this compound has never been marketed. Information about the current use of this compound is not available.
Status:
Investigational
Source:
Acta Endocrinol (Copenh). 1966;53:Suppl 111:3-26.: Not Applicable Human clinical trial Completed Menstruation Disturbances
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


Conditions:

Pregnanediol is a chief steroid metabolite of progesterone that is biologically inactive and occurs as pregnanediol glucuronate in the urine. Pregnanediol has two hydroxyl groups, at 3-alpha and 20-alpha. A test can be done to measure the amount of pregnanediol in urine. The urine test offers an indirect way to measure progesterone levels in the body. It is a standard in the colorimetric determination of urinary pregnanediol in clinical laboratories.
Status:
Investigational
Source:
INN:clentiazem
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Clentiazem is a chloride derivative of diltiazem, originated in Tanabe Seiyaku. It works as a blocker of calcium channels. The drug was investigated in the clinical trials for the treatment of stable angina, and essential hypertension. Despite the positive results of clinical trials, no development of the drug was reported.
Status:
Investigational
Source:
INN:pyrrolifene [INN]
Source URL:

Class (Stereo):
CHEMICAL (UNKNOWN)

Pyrroliphene is a dialkylaminodiphenylbutanol ester with antitussive and analgesic activities. In clinical trials the major side effect of Pyrroliphene was sedation, and the other side effect liabilities were similar to those of morphine.
Status:
Investigational
Source:
INN:cicortonide
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Cicortonide is a synthetic cyano-glucocorticoid with anti-inflammatory and antirheumatic, as well as antiallergenic properties.