6α-Hydroxyestradiol is one of major metabolites of endogenous estrogens, as well as a positional isomer of estriol. Transformation of estradiol to 6α-Hydroxyestradiol is a major metabolic pathway of estradiol in the liver. CYP1A2 and CYP3A4 are the major enzymes catalyzing the 6α-Hydroxyestradiol of estradiol.

17α-Epiestriol (17-epiestriol, 16α-hydroxy-17α-estradiol or estra-1,3,5(10)-triene-3,16α,17α-triol) is the 17α-epimer of estriol, a minor hydroxylated estradiol metabolite and a selective estrogen receptor (ER) beta agonist. 17α-Epiestriol is described as a relatively weak estrogen, which is in accordance with its relatively low affinity for the ERα. 17α-Epiestriol has been found to be approximately 400-fold more potent than estradiol in inhibiting tumor necrosis factor α (TNFα)-induced vascular cell adhesion molecule 1 (VCAM-1) expression in vitro.

Spiramycin 1 Acetate is a member of the Spiramycin macrolide family of bacterio static antibiotic compounds. The family of compounds was originally isolated from cultures of Streptomyces ambofaciens, a soil bacteria native to northern France. The mixture of Spiromycines has been separated into three classes I, II, III, which each have unique structural differences. The namesake compound spiramycin (aka Spiramycin Acetate in Japan) is approved for use as an antibiotic for the treatment of Gram-positive cocci and rods, Gram-negative cocci and Legionellae, mycoplasmas, chlamydiae, spirochetes, Toxoplasma gondii and some species of Cryptosporidium.