Indolebutyric acid (IBA) is a plant hormone in the auxin family. IBA promoted plant rooting and used commercially world wide to root many plant species. IBA considered to be toxic to animals and human. IBA demonstrated antineoplastic action in animal model. According to in silico and in vitro study IBA can act as competitive inhibitor to the phospholipase A₂ and may be used as anti inflammatory agent.

Cyclopamine is an inhibitor of hedgehog (Hh) signaling, likely via direct inhibition of Smoothened, the accessory protein to the putative Hh receptor Patched. Cyclopamine is a teratogen isolated from the corn lily that causes usually fatal birth defects. It can prevent the fetal brain from dividing into two lobes (holoprosencephaly) and cause the development of a single eye. Cyclopamine can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells. In the very first at any time human affected person with metastatic pancreatic most cancers who was administered intravenous cyclopamine on a compassionate, experimental basis in Germany, cyclopamine had to be discontinued because of emergence of neurologic toxicities and hematologic toxicities. That may possibly severely impede or even prevent scientific trials with this promising therapeutic technique.