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Restrict the search for
m nalidixic acid
to a specific field?
Class (Stereo):
CHEMICAL (MIXED)
Febuverine is a spasmolytic and local anesthetic.
Status:
Investigational
Source:
NCT00185042: Phase 2 Interventional Completed Coronary Heart Disease
(2002)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Daiichi Sankyo developed an inhibitor of acyl-coenzyme A:cholesterol acyltransferases (ACAT1 and ACAT2), pactimibe (also known as CS 505). Pactimibe has been used in trials phase II for reducing the progression of coronary artery disease and in patients with atherosclerosis. However, on October 26, 2005, the company made the decision to discontinue all ongoing clinical studies of pactimibe, because of the secondary endpoints that showed a lower effect of the drug on atherosclerosis than the standard of care alone and no beneficial effect on the frequency of cardiovascular events.
Class (Stereo):
CHEMICAL (RACEMIC)
Nafagrel [DP 1904, SR 96325] is a thromboxane A2 synthetase inhibitor that was undergoing clinical trials with Daiichi Seiyaku, now Daiichi Pharmaceutical, for the diabetic angiopathies, lupus nephritis and Raynaud's disease in Japan. However the development of Nafagrel has been discontinued.
Status:
Investigational
Source:
NCT00354250: Phase 2 Interventional Completed Recurrent Renal Cell Cancer
(2006)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Ispinesib (SB-715992) is a potent, specific and reversible inhibitor of kinesin spindle protein (KSP). KSP, also known as HsEg5, is a kinesin that plays an essential role in the formation of a bipolar mitotic spindle and is required for cell cycle progression through mitosis. Ispinesib is the highly specific small-molecule inhibitor of KSP tested for the treatment of human disease. It causes mitotic arrest and growth inhibition in several human tumor cell lines and is currently being tested in multiple phase II clinical trials for treatment of the breast cancer and renal cell cancer.
Class (Stereo):
CHEMICAL (ACHIRAL)
IPSALAZIDE is a sulfasalazine analog designed as a colon-specific delivery system for the treatment of inflammatory bowel disease by releasing 5-aminosalicylic acid in the gastrointestinal tract.
Status:
Investigational
Source:
INN:flubanilate [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
FLUBANILATE is a CNS stimulant.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Cefoxazole is a semi-synthetic, first-generation cephalosporin with bactericidal activity against penicillin-resistant strains of S. aureus and used in the treatment of bovine mastitis.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Etiproston is a synthetic analog of prostaglandin F2α. Etiproston induces luteal regression. Etiproston is used in veterinary.
Class (Stereo):
CHEMICAL (RACEMIC)
Esafloxacin (7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4 -dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid) is an antibacterial agent.
Class (Stereo):
CHEMICAL (ACHIRAL)
Niometacin, an indometacin derivative, is a nonsteroidal anti-inflammatory drug.
