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Restrict the search for
m nalidixic acid
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Class (Stereo):
CHEMICAL (RACEMIC)
Class (Stereo):
CHEMICAL (RACEMIC)
Dagapamil is a calcium-channel blocker, discovered by BASF. The compound is claimed to have antihypertensive, antiarrhythmic, cardioprotective, antiallergic and platelet aggregation-inhibiting action in animal models.
Status:
Investigational
Source:
USAN:CYPOTHRIN [USAN]
Source URL:
Class (Stereo):
CHEMICAL (UNKNOWN)
Cypothrin is a synthetic pyrethroid insecticide, developed by American Cyanamide for the control of ticks and marketed under the tradename Panecto. The compound exhibited systemic insecticidal activity in the model of flies infestation in mice and ixodicidal activity in against larvae of Boophilus microplus.
Status:
Investigational
Class (Stereo):
CHEMICAL (ABSOLUTE)
Amicus Therapeutics was investigating afegostat (isofagomine; Plicera; HGT-3410; AT-2101), an orally available pharmacological chaperone molecule, which binds to glucocerebrosidase (Gba) and stimulates proper folding and trafficking of the enzyme, for the potential treatment of Parkinsons disease(PD) and Gaucher disease. Afegostat specifically and reversibly binds GCase in the ER with highaffinity; this stabilizes the active form of the enzyme in the ER and increases trafficking of GCase to lysosomes. In 2006, Orphan Drug designations were granted in the U.S. and E.U. in 2006 and 2007, respectively. However, this research has been discontinued.
Class (Stereo):
CHEMICAL (MIXED)
Viprostol (also known as CL115,347), a prostaglandin E2 congener that was studied as an antihypertensive agent. Viprostol has a potent and prolonged blood pressure lowering effect in many models of hypertension. In clinical studies, viprostol has been demonstrated to lower arterial blood pressure significantly in man following transdermal and/or intravenous administration. The antihypertensive action of viprostol has been suggested to be the result of peripheral vasodilatation. In addition, the drug participated in a clinical trial in normal subjects and in patients with Raynaud's phenomenon. It was found the optimal dosage was 1000 ug; the effect could last for 84 hours; higher dosage may be associated with a "steal" phenomenon.
Status:
Investigational
Source:
INN:levomequitazine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Levomequitazine is the L-enantiomer of mequitazine. The antihistaminergic activity mainly resides in the S-enantiomer, L-mequitazine, whereas the anticholinergic activity mainly resides in the D-enantiomer. It was shown, that L-enantiomer of mequitazine is less potent antagonist of human M3 muscarinic acetylcholine receptors than D-enantiomer. In vitro binding studies have shown that the affinity of L-mequitazine for H1 receptors is approximately ten times higher and to muscarinic receptors ten times lower, compared to d-mequitazine. Memory impairment was observed after administration of L-mequitazine 10 mg alone on delayed recall. This could be due to indirect effects of H1 receptor blockade. L-mequitazine 10 mg produced mild driving impairment, whereas L-mequitazine 2.5 and 5.0 mg show no effects on driving. Levomequitazine had been in phase III clinical trials by Pierre Fabre for the treatment of perennial allergic rhinitis and seasonal allergic rhinitis.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Apadenoson (BMS-068645) is a selective adenosine 2A agonist that contains a methyl ester group which undergoes esterase hydrolysis to its acid metabolite. Apadenoson had been in phase III clinical trials by Forest (now a part of Allergan) for the treatment of coronary artery disease. However, this study has been terminated.
Status:
Investigational
Source:
INN:piridicillin [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Piridicillin is the semi-synthetic penicillin. It has exhibited broad-spectrum activity in vitro against gram-positive cocci, except penicillin G-resistant Staphylococcus aureus, and against gram-negative bacilli. Piridicillin is reported to be more active in-vitro than piperacillin, azlocillin or ticarcillin against Ps. aeruginosa. It is unstable at alkaline pH and displays marked inoculum independence.
Status:
Investigational
Source:
INN:ronacaleret [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Ronacaleret (SB-751689-A) is a calcium-sensing receptor antagonist. This orally administered compound has been evaluated as a drug for treatment of postmenopausal osteoporosis. By antagonizing calcium-sensing receptors on the surface of the parathyroid gland, ronacaleret triggers a transient release of the body's own stores of parathyroid hormone. In patients with osteoporosis, this may increase volumetric bone mineral. In a phase II clinical trial, bone mineral density at the lumbar spine increased. Cardiac disorders (2.3% of patients) and gastrointestinal disorders (>60% of patients) were reported as adverse events. Phase I studies have also been conducted to evaluate the impact of ronacaleret on mobilization of Hematopoietic stem cells (HSCs) and to measure changes in CD34+ cell counts.
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Nicotredole (Tryptamide), similarly to ibuprofen and piroxicam, shows anti-inflammatory and analgesic properties. Tryptamide reversed pyrogen-induced hyperthermia in rats, elicited analgesic effects in rats, but not in mice, prolonged the time of hexobarbital sleep in rats and inhibited locomotor activity in rats and mice. Tryptamide has not elicited side effects on the circulatory system of rats and cats.
