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Showing 191 - 200 of 10111 results

Status:
Investigational
Source:
Br J Clin Pharmacol. Aug 2024;90(8):1975-1983.: Not Applicable Human clinical trial Completed Vitamin B 12 Deficiency/blood
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Methylmalonic acid (MMA) is a C-methylated derivative of malonate. Elevated levels of methylmalonic acid result from inherited defects of enzymes involved in MMA metabolism or inherited or acquired deficiencies of vitamin B12 or its downstream metabolites. MMA is also a specific diagnostic marker for the group of disorders collectively called methylmalonic acidemia.
Status:
Investigational
Source:
INN:prodolic acid
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Prodolic acid is an indole derivative patented by American Home Products Corp. as antiinflammatory agent. Prodolic acid acts as non-steroidal anti-inflammatory compound and inhibits bradykinin-induced bronchoconstriction but did not affects histamine-induced bronchoconstriction in the guinea pig. In preclinical studies, Prodolic acid exhibits potent anti-inflammatory activity in adjuvant arthritic rats.
Status:
Investigational
Source:
INN:mercumatilin sodium
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Investigational
Source:
NCT00942656: Not Applicable Interventional Completed Cardiovascular Disease
(2009)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Rumenic acid is the major conjugated linoleic acid (CLA), probably because of successive desaturation and chain elongation and can be considered as the principal dietary form. In experiments on rodents was shown that rumenic acid possessed the protective effect against colitis, which was associated with the activation of the Nrf2 pathway.
Status:
Investigational
Source:
INN:foscolic acid
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Status:
Investigational
Source:
NCT03059160: Phase 2 Interventional Unknown status Rett Syndrome
(2017)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Tridecanoic acid is a 13-carbon saturated fatty acid found in dairy products and also as a product of anaerobic biodegradation of n-hexadecane. It has been identified as a substrate of phospholipase A2. Saturated fatty acids with carbon chain lengths of C12 to C14 activated the alpha-, beta-, gamma-, and epsilon-subspecies of the protein kinase C, and this activation was synergistic with that by diacylglycerol. Tridecanoic acid(C13) was most effective among the saturated fatty acids examined.
Status:
Investigational
Source:
USAN:SULFANILATE ZINC [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Conditions:

Sodium sulfanilate is a salt of sulphanilic acid and has been used to monitor the degree of renal dysfunction in dogs.
Status:
Investigational
Source:
INN:iocanlidic acid (¹²³I) [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Iocanlidic Acid I-123 is a radiolabeled phenylfatty acid derivative studied as a diagnostic agent for myocardial imaging
Status:
Investigational
Source:
NCT00741442: Phase 2 Interventional Completed Hyperuricemia
(2008)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
USAN:UNDECANOATE [USAN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Undecanoic acid (UDA) is a fatty acid with significant antimycotic activity. Undecanoic acid is a straight-chain, eleven-carbon saturated medium-chain fatty acid found in body fluids; the most fungitoxic of the C7:0 - C18:0 fatty acid series. It has a role as a human metabolite and an antifungal agent. It is a straight-chain saturated fatty acid and a medium-chain fatty acid. It is a conjugate acid of an undecanoate. It derives from a hydride of an undecane. Undecanoic acid inhibited the production of exocellular lipase and keratinase but stimulated the production of exocellular phospholipase A in T. rubrum undecanoic acid-resistant mutant (udar). At its minimum inhibitory concentration, undecanoic acid inhibits biosynthesis of phosphatidyl serine, phosphatidyl ethanolamine and polyphosphoinositol but does not inhibit the synthesis of phosphatidyl glycerol, phosphatidyl choline, phosphatidyl inositol and phosphatidic acid in Trichophyton rubrum. At higher concentration, however UDA inhibits biosynthesis of all phosphatides present in this dermatophyte. UDA also affects catabolism of these phosphatides. This inhibitory effect of UDA may be partially responsible for its toxic action on T. rubrum.