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Restrict the search for
theophylline
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Status:
Investigational
Source:
INN:guaifylline [INN]
Source URL:
Class (Stereo):
CHEMICAL (RACEMIC)
Guaithylline (or Guaifylline), a xanthine derivative that was studied as a bronchodilator and expectorant, however, has never been marketed.
Status:
Class (Stereo):
CHEMICAL (RACEMIC)
Class (Stereo):
CHEMICAL (ACHIRAL)
Dimethazan is a caffeine derivative. Dimethazan differs from caffeine by the replacement of the third methyl group. Dimethazan possesses antidepressant and diuretic properties. Dimethazan, administered intravenously to geriatric patients, produced respiratory and cerebral stimulation in the majority of cases. The clinical utilization of the respiratory stimulatory effect was confirmed in a patient markedly depressed with chlorpromazine. Oral administration to patients hospitalized for treatment of mental and physical depression indicated a dual effect: central nervous system stimulation and sedation. It is safe and well tolerated with none of the shortcomings of other caffeine preparations.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Tameridone is a neurotransmitter antagonist was developed as a psychotropic agent for use in veterinary. Information about the current use of this drug is not available.
Class (Stereo):
CHEMICAL (ACHIRAL)
Nestifylline [ABC 99] is a methylxanthine derivative that was at the preclinical stage of development with ABC for the treatment of asthma. ABC 99 has been studied in the animal to evaluate its pharmacological activity. This compound was found to have antibronchospastic activity in vitro and in vivo markedly greater than aminophylline. The new compound also had moderate antitussic properties and was an active mucoregulator. ABC 99 acts as an intestinal muscle relaxant, but it has no cardiovascular, urinary, or CNS side effects. The mechanism of ABC 99 could be explained by its inhibition of guinea-pig lung phosphodiesterases and affinity for adenosine receptors, particularly A2 receptors. ABC 99 was observed to have marked anti-inflammatory activity in a series of experimental trials involving the principal mediators of inflammation (PAF, histamine, serotonin, LTC4-like substances, etc). ABC 99 is of particular interest in the treatment of respiratory disorders involving obstructive inflammation and bronchial hypersensitivity.
Status:
Investigational
Source:
INN:pimefylline [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Pimefylline is an N-methylated xanthine derivative. It is a coronary vasodilator and muscle relaxant.
Class (Stereo):
CHEMICAL (RACEMIC)
Diniprofylline is a vasodilator, broncholytic agent and respiratory stimulant used in severe respiratory insufficiencies.
Class (Stereo):
CHEMICAL (RACEMIC)
Triclofylline is a N-methylated xanthine derivative. It was developed as an anti-asthmatic drug.
Class (Stereo):
CHEMICAL (ACHIRAL)
Fluprofylline, a central stimulant, was a very selective though not very potent alpha 1-adrenoceptor antagonist. However, information about the further development of this compound is not available.
Status:
Investigational
Source:
INN:metescufylline [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
