FLUPROFYLLINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C22H26FN5O3
Molecular Weight	427.4719
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1C2=C(N(CCCN3CCC(CC3)C(=O)C4=CC=C(F)C=C4)C=N2)C(=O)N(C)C1=O

InChI

InChIKey=IPSYNNODBHPDFB-UHFFFAOYSA-N

InChI=1S/C22H26FN5O3/c1-25-20-18(21(30)26(2)22(25)31)28(14-24-20)11-3-10-27-12-8-16(9-13-27)19(29)15-4-6-17(23)7-5-15/h4-7,14,16H,3,8-13H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C22H26FN5O3
Molecular Weight	427.4719
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2872314

Fluprofylline, a central stimulant, was a very selective though not very potent alpha 1-adrenoceptor antagonist. However, information about the further development of this compound is not available.

Approval Year

PubMed

Title	Date	PubMed
[New biologically active theophylline derivatives. Synthesis and pharmacologic properties of flufylline and fluprofylline].	1984	6608355
Characterization of flufylline, fluprofylline, ritanserin, butanserin and R 56413 with respect to in-vivo alpha 1-,alpha 2- and 5-HT2-receptor antagonism and in-vitro affinity for alpha 1-,alpha 2- and 5-HT2-receptors: comparison with ketanserin.	1986 May	2872314

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:47:55 UTC 2023` Edited by `admin` on `Fri Dec 15 15:47:55 UTC 2023`
Record UNII	6Y42K4JRBJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLUPROFYLLINE

Official Name

English

fluprofylline [INN]

Common Name

English

7-(3-(4-(P-FLUOROBENZOYL)PIPERIDINO)PROPYL)THEOPHYLLINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C319