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Restrict the search for
octreotide
to a specific field?
Status:
Possibly Marketed Outside US
Source:
NCT03349424: Phase 4 Interventional Completed Pancreatic Fistula
(2018)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Somatostatin (also known as growth hormone-inhibiting hormone) is a naturally-occurring peptide hormone that regulates the endocrine system. Somatostatin is produced in gastrointestinal (GI) tract, pancreas, hypothalamus, and central nervous system (CNS) and some other organs. Somatostatin is initially secreted as a 116 amino acid precursor, preprosomatostatin, which undergoes endoproteolytic cleavage to prosomastatin. Prosomastatin is further process into two active forms, shorter isoform somatostatin-14 works primarily in the brain, while the longer somatostatin-28 (SST-28) form operates in the GI tract. Somatostatin produces predominantly neuroendocrine inhibitory effects across multiple systems. It is known to inhibit GI, endocrine, exocrine, pancreatic, and pituitary secretions, as well as modify neurotransmission and memory formation in the CNS. Somatostatin binds to six different receptors in various systems and cells throughout the body to produce its regulatory effect. These receptors are specific to somatostatin and classify as G-protein coupled receptors (GPCR). Somatostatin half-life is between 1 to 3 minutes. Due to its short half-life, somatostatin has been formulated exogenously in much more stable forms with a longer half-life; this allows for its primary clinical use, which is the treatment of neuroendocrine tumors.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Possibly Marketed Outside US
Source:
NCT01321996: Phase 4 Interventional Terminated Idiopathic Pulmonary Fibrosis
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Class:
PROTEIN
Ilatreotide was developed as a somatostatin receptor agonist with potential for treating gastroenteropancreatic tumors. It is an orally active pituitary and guts hormonal secretion inhibitor.
