Approval Year
| Substance Class |
Protein
Created
by
admin
on
Edited
Sat Dec 16 12:10:06 UTC 2023
by
admin
on
Sat Dec 16 12:10:06 UTC 2023
|
| Protein Sub Type | |
| Sequence Type | COMPLETE |
| Record UNII |
D73QL0OMU2
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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P30874
Created by
admin on Sat Dec 16 12:10:08 UTC 2023 , Edited by admin on Sat Dec 16 12:10:08 UTC 2023
|
PRIMARY | |||
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391971-42-9
Created by
admin on Sat Dec 16 12:10:08 UTC 2023 , Edited by admin on Sat Dec 16 12:10:08 UTC 2023
|
PRIMARY | |||
|
D73QL0OMU2
Created by
admin on Sat Dec 16 12:10:08 UTC 2023 , Edited by admin on Sat Dec 16 12:10:08 UTC 2023
|
PRIMARY |
| From | To |
|---|---|
| 1_115 | 1_193 |
| Glycosylation Type | HUMAN |
| Glycosylation Link Type | Site |
|---|---|
| N | 1_9 |
| N | 1_22 |
| N | 1_29 |
| N | 1_32 |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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RADIOLIGAND->TARGET |
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RADIOLIGAND->TARGET |
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RADIOLIGAND->TARGET |
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INHIBITOR -> TARGET |
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RADIOLIGAND->TARGET | |||
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INHIBITOR -> TARGET | |||
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AGONIST -> TARGET |
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INHIBITOR -> TARGET | |||
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LIGAND->TARGET |
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LIGAND->TARGET |
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RADIOLIGAND->TARGET | |||
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RADIOLIGAND->TARGET |
ALPHA-PARTICLE EMITTING RADIONUCLIDE
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RADIOLIGAND->TARGET |
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AGONIST -> TARGET |
EC50
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AGONIST -> TARGET |
IN-VITRO
IC50
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LIGAND->TARGET |
IN-VITRO
IC50
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RADIOLIGAND->TARGET |
Lutetium Lu 177 dotatate binds to somatostatin receptors with highest affinity for subtype 2 receptors (SSRT2). Upon binding to somatostatin receptor expressing cells, including malignant somatostatin receptor-positive tumors, the compound is internalized. The beta emission from Lu 177 induces cellular damage by formation of free radicals in somatostatin receptor-positive cells and in neighboring cells.
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RADIOLIGAND->TARGET | |||
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RADIOLIGAND->TARGET |
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INHIBITOR -> TARGET |
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RADIOLIGAND->TARGET |
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INHIBITOR -> TARGET | |||
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LIGAND->TARGET |
XmAb18087 Binding to Human SSTR2 Antigens Heterologously Expressed on the Surface of CHO Cells.
BINDING
EC50
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LIGAND->TARGET |
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RADIOLIGAND->TARGET |
| Name | Property Type | Amount | Referenced Substance | Defining | Parameters | References |
|---|---|---|---|---|---|---|
| MOL_WEIGHT | CHEMICAL |
|