DEPREOTIDE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C65H96N16O12S2
Molecular Weight	1357.688
Optical Activity	UNSPECIFIED
Defined Stereocenters	10 / 10
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC4=CC=C(O)C=C4)NC(=O)[C@H](CC5=CC=CC=C5)N(C)C(=O)[C@H](CCSCC(=O)NC[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(N)=O)NC1=O

InChI

InChIKey=XXXSJQLZVNKRKX-YQRDHHIGSA-N

InChI=1S/C65H96N16O12S2/c1-38(2)55-64(92)76-49(26-30-95-37-54(83)72-35-44(69)57(85)74-47(20-10-13-28-67)58(86)79-52(36-94)62(90)73-46(56(70)84)19-9-12-27-66)65(93)81(3)53(32-39-15-5-4-6-16-39)63(91)78-50(31-40-22-24-42(82)25-23-40)60(88)77-51(33-41-34-71-45-18-8-7-17-43(41)45)61(89)75-48(59(87)80-55)21-11-14-29-68/h4-8,15-18,22-25,34,38,44,46-53,55,71,82,94H,9-14,19-21,26-33,35-37,66-69H2,1-3H3,(H2,70,84)(H,72,83)(H,73,90)(H,74,85)(H,75,89)(H,76,92)(H,77,88)(H,78,91)(H,79,86)(H,80,87)/t44-,46-,47-,48-,49-,50-,51+,52-,53-,55-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C65H96N16O12S2
Molecular Weight	1357.688
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	10 / 10
E/Z Centers	2
Optical Activity	UNSPECIFIED

Description
Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/21012s007lbl.pdf | https://www.drugfuture.com/chemdata/depreotide.html | https://www.rxlist.com/neotect-drug.htm | https://www.ema.europa.eu/en/documents/product-information/neospect-epar-product-information_en.pdf

Depreotide is an ingredient in the diagnostic aid (radioactive imaging agent). Technetium Tc 99m labeled depreotide is a scintigraphic imaging agent that identifies somatostatin receptor-bearing pulmonary masses in patients presenting with pulmonary lesions on computed tomography and/or chest x-ray who have known malignancy or who are highly suspect for malignancy. Adverse events were evaluated in clinical studies of 647 adults. Deaths did not occur during the clinical study period. After Technetium Tc 99m Depreotide Injection, serious adverse events were not reported. Headache was the most commonly reported adverse event. EMA withdrew depreotide containing agent NeoSpect.

Approval Year

Patents

Sample Use Guides

In Vivo Use Guide

Single dose of 15 to 20 mCi containing approximately 47ug of Technetium Tc 99m radiolabeled Depreotide peptide.

Route of Administration: Intravenous

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:45:05 GMT 2023` Edited by `admin` on `Fri Dec 15 15:45:05 GMT 2023`
Record UNII	NDP0H8E844
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DEPREOTIDE

Official Name

English

DEPREOTIDE [MI]

Common Name

English

CYCLO(L-HOMOCYSTEINYL-N-METHYL-L-PHENYLALANYL-L-TYROSYL-D-TRYPTOPHYL-L-LYSYL-L-VALYL), (1->1')-SULFIDE WITH 3-(2-MERCAPTOACETAMIDO)-L-ALANYL-L-LYSYL-L-CYSTEINYL-L-LYSINAMIDE

Common Name

English

DEPREOTIDE [USAN]

Common Name

English

CYCLO(L-HOMOCYSTEINYL-N-METHYL-L-PHENYLALANYL-L-TYROSYL-D-TRYPTOPHYL-L-LYSYL-L-VALYL) (1->1')-SULPHIDE WITH 3-((MERCAPTOACETYL)AMINO)-L-ALANYL-L-LYSYL-L-CYSTEINYL-L-LYSINAMIDE

Common Name

English

Depreotide [WHO-DD]

Common Name

English

P-829

Code

English

depreotide [INN]

Common Name

English

CYCLO(L-HOMOCYSTEINYL-N-METHYL-L-PHENYLALANYL-L-TYROSYL-D-TRYPTOPHYL-L-LYSYL-L-VALYL) (1->1')-SULFIDE WITH 3-((MERCAPTOACETYL)AMINO)-L-ALANYL-L-LYSYL-L-CYSTEINYL-L-LYSINAMIDE

Common Name

English

CYCLO(L-HOMOCYSTEINYL-N-METHYL-L-PHENYLALANYL-L-TYROSYL-D-TRYPTOPHYL-L-LYSYL-L-VALYL), (1->1')-SULPHIDE WITH 3-(2-MERCAPTOACETAMIDO)-L-ALANYL-L-LYSYL-L-CYSTEINYL-L-LYSINAMIDE

Common Name

English

P829

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C62799