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Details

Stereochemistry ABSOLUTE
Molecular Formula C65H87N14O19S2.Ga
Molecular Weight 1500.5314
Optical Activity UNSPECIFIED
Defined Stereocenters 10 / 10
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GALLIUM OXODOTREOTIDE GA-68

SMILES

[68Ga+3].CC(O)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)CN3CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC3)C(=O)N[C@@H](CC4=CC=C(O)C=C4)C(=O)N[C@H](CC5=CNC6=C5C=CC=C6)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(O)=O

InChI

InChIKey=XBJPSVQFCQFGDC-WSCOIBMGSA-K
InChI=1S/C65H90N14O19S2.Ga/c1-38(80)56-64(96)73-51(63(95)75-57(39(2)81)65(97)98)37-100-99-36-50(72-59(91)47(28-40-10-4-3-5-11-40)68-52(83)32-76-20-22-77(33-53(84)85)24-26-79(35-55(88)89)27-25-78(23-21-76)34-54(86)87)62(94)70-48(29-41-15-17-43(82)18-16-41)60(92)71-49(30-42-31-67-45-13-7-6-12-44(42)45)61(93)69-46(58(90)74-56)14-8-9-19-66;/h3-7,10-13,15-18,31,38-39,46-51,56-57,67,80-82H,8-9,14,19-30,32-37,66H2,1-2H3,(H,68,83)(H,69,93)(H,70,94)(H,71,92)(H,72,91)(H,73,96)(H,74,90)(H,75,95)(H,84,85)(H,86,87)(H,88,89)(H,97,98);/q;+3/p-3/t38-,39-,46+,47-,48+,49-,50+,51+,56+,57+;/m1./s1/i;1-2

HIDE SMILES / InChI
Molecular Formula C65H87N14O19S2
Molecular Weight 1432.6034
Charge -3
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 10 / 10
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula Ga
Molecular Weight 67.928
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Dotatate gallium (Ga-68) (Ga-DOTATATE ) under the brand name NETSPOT is indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients. In addition, was shown, that Ga-DOTATATE can be used for detection the incidental medullary thyroid carcinoma. It binds to cells that express somatostatin receptors including malignant cells, which overexpress somatostatin subtype 2 receptors.

Originator

Approval Year

2016
494
Targets

Targets

Primary TargetPharmacologyConditionPotency
Somatostatin receptor type 2
2
Target ID: P30874
Gene ID: 6752.0
Gene Symbol: SSTR2
Target Organism: Homo sapiens (Human)
Binding Agent
1076
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
Approved
8583
NETSPOT

Approved Use

NETSPOT, after radiolabeling with Ga 68, is a radioactive diagnostic agent indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients

Launch Date

2016
Diagnostic
Not Provided
511
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
68Ga-DOTATATE PET/CT Reveals Epstein-Barr Virus-Associated Nasopharyngeal Carcinoma in a Case of Suspected Sphenoid Wing Meningioma.
2018-04
Incidental Detection of Medullary Thyroid Carcinoma by 68Ga-DOTATATE PET/CT in a Patient With Neuroendocrine Tumor Liver Metastases.
2018-02
Specific somatostatin receptor II expression in arterial plaque: (68)Ga-DOTATATE autoradiographic, immunohistochemical and flow cytometric studies in apoE-deficient mice.
2013-09
Clinical applications of Gallium-68.
2013-06
Comparison of 68Ga-DOTANOC and 68Ga-DOTATATE PET/CT within patients with gastroenteropancreatic neuroendocrine tumors.
2013-03

Sample Use Guides

In Vivo Use Guide
In adults and pediatric patients, the recommended amount of radioactivity to be administered for positron emission tomography (PET) imaging is 2 MBq/kg of body weight (0.054 mCi/kg) up to 200 MBq (5.4 mCi).
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Mon Mar 31 20:59:52 GMT 2025
Edited
by admin
on Mon Mar 31 20:59:52 GMT 2025
Record UNII
9L17Y0H71P
Record Status FAILED
Record Version
  • Download
Name Type Language
GALLIUM OXODOTREOTIDE GA-68
Common Name English
DOTATATE GALLIUM GA-68
DASH  
Preferred Name English
GALLIUM DOTATATE GA-68 [ORANGE BOOK]
Common Name English
GATATE
Brand Name English
68GA-DOTATATE
Common Name English
GALLIUM DOTATATE GA-68
Common Name English
GALIOMEDIX
Brand Name English
GALLIUM (Ga68) DOTATATE
Common Name English
GALLIUM-DOTA-OCTREOTATE GA-68
Common Name English
GALLIUM 68 DOTATATE
Common Name English
GALLIUM-DOTA-OCTREOTATE, GA-68
Common Name English
GALLIUM DOTATATE, GA-68
Common Name English
GALLIUM GA 68 DOTATATE
Common Name English
[68GA]GALLIUM DOTATATE
Common Name English
DOTA-OCTREOTATE GALLIUM GA-68
Common Name English
Gallium (68Ga) dotatate [WHO-DD]
Common Name English
GALLIUM (68GA) DOTA-TATE
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 404813
Created by admin on Mon Mar 31 20:59:52 GMT 2025 , Edited by admin on Mon Mar 31 20:59:52 GMT 2025
NDF-RT N0000177914
Created by admin on Mon Mar 31 20:59:52 GMT 2025 , Edited by admin on Mon Mar 31 20:59:52 GMT 2025
Code System Code Type Description
FDA UNII
9L17Y0H71P
Created by admin on Mon Mar 31 20:59:52 GMT 2025 , Edited by admin on Mon Mar 31 20:59:52 GMT 2025
PRIMARY
SMS_ID
100000175726
Created by admin on Mon Mar 31 20:59:52 GMT 2025 , Edited by admin on Mon Mar 31 20:59:52 GMT 2025
PRIMARY
DRUG CENTRAL
5156
Created by admin on Mon Mar 31 20:59:52 GMT 2025 , Edited by admin on Mon Mar 31 20:59:52 GMT 2025
PRIMARY
DAILYMED
9L17Y0H71P
Created by admin on Mon Mar 31 20:59:52 GMT 2025 , Edited by admin on Mon Mar 31 20:59:52 GMT 2025
PRIMARY
NCI_THESAURUS
C97661
Created by admin on Mon Mar 31 20:59:52 GMT 2025 , Edited by admin on Mon Mar 31 20:59:52 GMT 2025
PRIMARY
LACTMED
Gallium Ga 68 Dotatate
Created by admin on Mon Mar 31 20:59:52 GMT 2025 , Edited by admin on Mon Mar 31 20:59:52 GMT 2025
PRIMARY
PUBCHEM
131634491
Created by admin on Mon Mar 31 20:59:52 GMT 2025 , Edited by admin on Mon Mar 31 20:59:52 GMT 2025
PRIMARY
DRUG BANK
DB13925
Created by admin on Mon Mar 31 20:59:52 GMT 2025 , Edited by admin on Mon Mar 31 20:59:52 GMT 2025
PRIMARY
CAS
1027785-90-5
Created by admin on Mon Mar 31 20:59:52 GMT 2025 , Edited by admin on Mon Mar 31 20:59:52 GMT 2025
PRIMARY
NDF-RT
N0000175869
Created by admin on Mon Mar 31 20:59:52 GMT 2025 , Edited by admin on Mon Mar 31 20:59:52 GMT 2025
PRIMARY Positron Emitting Activity [MoA]
RXCUI
676679
Created by admin on Mon Mar 31 20:59:52 GMT 2025 , Edited by admin on Mon Mar 31 20:59:52 GMT 2025
PRIMARY
Related Record Type Details
Structure of OXODOTREOTIDE
PARENT -> SALT/SOLVATE
SOMATOSTATIN RECEPTOR TYPE 2
TARGET->RADIOLIGAND
Related Record Type Details
Structure of GALLIUM OXODOTREOTIDE GA-68
ACTIVE MOIETY
NIH
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