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Details

Stereochemistry ABSOLUTE
Molecular Formula C65H87N14O19S2.Ga
Molecular Weight 1500.527
Optical Activity UNSPECIFIED
Defined Stereocenters 10 / 10
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GALLIUM OXODOTREOTIDE GA-68

SMILES

[68Ga+3].CC(O)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)CN3CCN(CC([O-])=O)CCN(CC([O-])=O)CCN(CC([O-])=O)CC3)C(=O)N[C@@H](CC4=CC=C(O)C=C4)C(=O)N[C@H](CC5=CNC6=C5C=CC=C6)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(O)=O

InChI

InChIKey=XBJPSVQFCQFGDC-WSCOIBMGSA-K
InChI=1S/C65H90N14O19S2.Ga/c1-38(80)56-64(96)73-51(63(95)75-57(39(2)81)65(97)98)37-100-99-36-50(72-59(91)47(28-40-10-4-3-5-11-40)68-52(83)32-76-20-22-77(33-53(84)85)24-26-79(35-55(88)89)27-25-78(23-21-76)34-54(86)87)62(94)70-48(29-41-15-17-43(82)18-16-41)60(92)71-49(30-42-31-67-45-13-7-6-12-44(42)45)61(93)69-46(58(90)74-56)14-8-9-19-66;/h3-7,10-13,15-18,31,38-39,46-51,56-57,67,80-82H,8-9,14,19-30,32-37,66H2,1-2H3,(H,68,83)(H,69,93)(H,70,94)(H,71,92)(H,72,91)(H,73,96)(H,74,90)(H,75,95)(H,84,85)(H,86,87)(H,88,89)(H,97,98);/q;+3/p-3/t38-,39-,46+,47-,48+,49-,50+,51+,56+,57+;/m1./s1/i;1-2

HIDE SMILES / InChI

Molecular Formula C65H87N14O19S2
Molecular Weight 1432.599
Charge -3
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 10 / 10
E/Z Centers 1
Optical Activity UNSPECIFIED

Molecular Formula Ga
Molecular Weight 67.928
Charge 3
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Dotatate gallium (Ga-68) (Ga-DOTATATE ) under the brand name NETSPOT is indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients. In addition, was shown, that Ga-DOTATATE can be used for detection the incidental medullary thyroid carcinoma. It binds to cells that express somatostatin receptors including malignant cells, which overexpress somatostatin subtype 2 receptors.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: P30874
Gene ID: 6752.0
Gene Symbol: SSTR2
Target Organism: Homo sapiens (Human)
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
NETSPOT

Approved Use

NETSPOT, after radiolabeling with Ga 68, is a radioactive diagnostic agent indicated for use with positron emission tomography (PET) for localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients

Launch Date

1.46465279E12
Diagnostic
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Specific somatostatin receptor II expression in arterial plaque: (68)Ga-DOTATATE autoradiographic, immunohistochemical and flow cytometric studies in apoE-deficient mice.
2013 Sep

Sample Use Guides

In adults and pediatric patients, the recommended amount of radioactivity to be administered for positron emission tomography (PET) imaging is 2 MBq/kg of body weight (0.054 mCi/kg) up to 200 MBq (5.4 mCi).
Route of Administration: Intravenous
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 01:46:34 UTC 2023
Edited
by admin
on Sat Dec 16 01:46:34 UTC 2023
Record UNII
9L17Y0H71P
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
GALLIUM OXODOTREOTIDE GA-68
Common Name English
GALLIUM DOTATATE GA-68 [ORANGE BOOK]
Common Name English
DOTATATE GALLIUM GA-68
DASH  
Common Name English
GATATE
Brand Name English
68GA-DOTATATE
Common Name English
GALLIUM DOTATATE GA-68
Common Name English
GALIOMEDIX
Brand Name English
GALLIUM (Ga68) DOTATATE
Common Name English
GALLIUM-DOTA-OCTREOTATE GA-68
Common Name English
GALLIUM 68 DOTATATE
Common Name English
GALLIUM-DOTA-OCTREOTATE, GA-68
Common Name English
GALLIUM DOTATATE, GA-68
Common Name English
GALLIUM GA 68 DOTATATE
Common Name English
[68GA]GALLIUM DOTATATE
Common Name English
DOTA-OCTREOTATE GALLIUM GA-68
Common Name English
Gallium (68Ga) dotatate [WHO-DD]
Common Name English
GALLIUM (68GA) DOTA-TATE
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 404813
Created by admin on Sat Dec 16 01:46:34 UTC 2023 , Edited by admin on Sat Dec 16 01:46:34 UTC 2023
NDF-RT N0000177914
Created by admin on Sat Dec 16 01:46:34 UTC 2023 , Edited by admin on Sat Dec 16 01:46:34 UTC 2023
Code System Code Type Description
FDA UNII
9L17Y0H71P
Created by admin on Sat Dec 16 01:46:34 UTC 2023 , Edited by admin on Sat Dec 16 01:46:34 UTC 2023
PRIMARY
SMS_ID
100000175726
Created by admin on Sat Dec 16 01:46:34 UTC 2023 , Edited by admin on Sat Dec 16 01:46:34 UTC 2023
PRIMARY
DRUG CENTRAL
5156
Created by admin on Sat Dec 16 01:46:34 UTC 2023 , Edited by admin on Sat Dec 16 01:46:34 UTC 2023
PRIMARY
DAILYMED
9L17Y0H71P
Created by admin on Sat Dec 16 01:46:34 UTC 2023 , Edited by admin on Sat Dec 16 01:46:34 UTC 2023
PRIMARY
NCI_THESAURUS
C97661
Created by admin on Sat Dec 16 01:46:34 UTC 2023 , Edited by admin on Sat Dec 16 01:46:34 UTC 2023
PRIMARY
LACTMED
Gallium Ga 68 Dotatate
Created by admin on Sat Dec 16 01:46:34 UTC 2023 , Edited by admin on Sat Dec 16 01:46:34 UTC 2023
PRIMARY
PUBCHEM
131634491
Created by admin on Sat Dec 16 01:46:34 UTC 2023 , Edited by admin on Sat Dec 16 01:46:34 UTC 2023
PRIMARY
DRUG BANK
DB13925
Created by admin on Sat Dec 16 01:46:34 UTC 2023 , Edited by admin on Sat Dec 16 01:46:34 UTC 2023
PRIMARY
CAS
1027785-90-5
Created by admin on Sat Dec 16 01:46:34 UTC 2023 , Edited by admin on Sat Dec 16 01:46:34 UTC 2023
PRIMARY
NDF-RT
N0000175869
Created by admin on Sat Dec 16 01:46:34 UTC 2023 , Edited by admin on Sat Dec 16 01:46:34 UTC 2023
PRIMARY Positron Emitting Activity [MoA]
RXCUI
676679
Created by admin on Sat Dec 16 01:46:34 UTC 2023 , Edited by admin on Sat Dec 16 01:46:34 UTC 2023
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE
TARGET->RADIOLIGAND
Related Record Type Details
ACTIVE MOIETY