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Restrict the search for
alpha-tocopherol acetate
to a specific field?
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Berlafenone (previously known as GK 23 G), a sodium channel antagonist was studied as a class Ic antiarrhythmic agent, but development has been discontinued.
Status:
Investigational
Source:
NCT00382811: Phase 3 Interventional Completed Fallopian Tube Cancer
(2006)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Idronoxil (Phenoxodiol) is a synthetic flavonoid derivative developed by MEI Pharma for cancer treatment. Idronoxil inhibits proliferation of many cancer cell lines and induces apoptosis by disrupting FLICE-inhibitory protein, FLIP, expression and by caspase-dependent and -independent degradation of the X-linked inhibitor of apoptosis, XIAP. In addition, Idronoxil sensitizes drug-resistant tumour cells to anticancer drugs including paclitaxel, carboplatin, and gemcitabine. The antiproliferative effects of Idronoxil are associated with inhibition of plasma membrane electron transport in tumour cell lines and primary immune cells. Idronoxil displays anti-cancer activity against all forms of cancer tested in vitro and in vivo to date, using cells representative of all major forms of cancer. While having a modest ability to kill cancer cells(IC50 range between about 1-5 uM), preclinical studies point to its optimal use being to sensitize cancer cells to the toxic effects of standard therapies (chemotherapy and radiotherapy). The rationale is that a sub-lethal inhibitory effect on sphingosine kinase activity reduces the ability of the cancer cell to operate drug-resistance mechanisms and to effect repair of drug- or radiation-induced damage to DNA. In the case of cytotoxic drugs such as cisplatin, carboplatin, paclitaxel, Doxorubicin, and gemcitabine, Idronoxil is an exquisite sensitizer, increasing the cytotoxic potential of those agents by between 103 -105 times, in the process restoring sensitivity to cancer cells highly refractory to those agents.
Status:
Investigational
Source:
NCT00035503: Phase 2 Interventional Completed Crohn's Disease
(2002)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Etiprednol dicloacetate (BNP-166; ethyl-17alpha-dichloroacetoxy-11beta-hydroxyandrosta-1,4-diene-3-one-17beta-carboxylate) is a new soft steroid. The compound proved to be a dissociated glucocorticoid, showing a reduction in transactivating activity while preserving transrepressive abilities. The compound effectively decreased cytokine production in lipopolysaccharide-stimulated lymphocytes and attenuated lectin-induced proliferation of blood mononuclear cells in tissue culture. The significant local effect of the compound will very likely be accompanied by a drastically reduced systemic activity indicating an encouraging selectivity of the pharmacological action of etiprednol dicloacetate. Etiprednol dicloacetate had been in a clinical trial for the treatment of allergic rhinitis, asthma and Crohn's disease. However, development has been discontinued.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Vinmegallate (also known as RGH-4417) was developed as a topical dermatological agent for the treatment of psoriasis. Vinmegallate is a phosphodiesterase inhibitor. However, information about the further development of this agent is not available.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Hydromadinone is a steroidal progestin that has never been marketed.
Class (Stereo):
CHEMICAL (ACHIRAL)
Acefurtiamine is a vitamin B1 analog. It is as an analgesic.
Status:
Investigational
Source:
INN:difenoximide [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Difenoximide is a water insoluble derivative of diphenoxylate, a chemical congener of meperidine. Difenoximide has been shown to have a greater ability than methadone to suppress opiate withdrawal in addicted mice and it has produced less physical dependence than morphine and methadone in laboratory animals. Since diphenoxylic acid is the major metabolite of both difenoximide and diphenoxylate, it is assumed that difenoximide will have essentially the same dependence liability and long-term toxicologic effects as those of diphenoxylate. Difenoximide has been given to human volunteers and it showed antidiarrheal action without side effects. Difenoximide appeared to be a potentially useful agent for ambulatory narcotic detoxification. The only significant side-effect was constipation.
Status:
Investigational
Class (Stereo):
CHEMICAL (ABSOLUTE)
Oxfenicine is a CPT-1b-specific inhibitor. It must be transaminated to its active form, 4-hydroxyphenyl-glyoxylate, which is competitive with carnitine, preventing the formation of acylcarnitine. Because CPT-1b shows the highest sensitivity to 4-hydroxyphenyl-glyoxylate, inhibition of fatty acid oxidation by oxfenicine takes place selectively in those tissues that express this CPT isoform. It may be effective for treating noninsulin-dependent diabetes mellitus which is characterized by elevated fatty acid levels and obesity. In 1980 it was also tested in preclinical models of angina pectoris and ischemia.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Meteneprost (9-deoxo-16, 16-dimethyl-9-methylene PGE2) is a prostaglandin E2 analog. It exerts uterine-stimulating potency: meteneprost is able to both stimulate uterine contractions and dilate the cervical canal. It was studied as an abortifacient in early pregnancy.
Class (Stereo):
CHEMICAL (RACEMIC)
Estrazinol is a synthetic estrogen.
