BERLAFENONE

Investigational

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H25NO2
Molecular Weight	299.4073
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC(C)(C)NCC(O)COC1=C(C=CC=C1)C2=CC=CC=C2

InChI

InChIKey=DBHPVKNFKBKJCE-UHFFFAOYSA-N

InChI=1S/C19H25NO2/c1-19(2,3)20-13-16(21)14-22-18-12-8-7-11-17(18)15-9-5-4-6-10-15/h4-12,16,20-21H,13-14H2,1-3H3

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Description

Berlafenone (previously known as GK 23 G), a sodium channel antagonist was studied as a class Ic antiarrhythmic agent, but development has been discontinued.

Originator

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Sodium channel alpha subunit 76	Blocker 537

PubMed

Show entries

Title	Date	PubMed
Negative inotropic effects of the new class I antiarrhythmic agents berlafenone and alprafenone on electrically stimulated isolated cardiomyocytes.	1992 Mar	1497686

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Patents

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Name

Type

Language

BERLAFENONE

Official Name

English

(±)-1-(2-BIPHENYLYLOXY)-3-(TERT-BUTYLAMINO)-2-PROPANOL

Systematic Name

English

berlafenone [INN]

Common Name

English

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Classification Tree

Code System

Code

Agent Affecting Cardiovascular System

NCI_THESAURUS

C47793

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Code System

Code

Type

Description

PUBCHEM

65691

PRIMARY

FDA UNII

4MYE3XA3GV

PRIMARY

INN

6597

PRIMARY

ChEMBL

CHEMBL2104145

PRIMARY

CAS

18965-97-4

PRIMARY

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ACTIVE MOIETY


					4MYE3XA3GV

BERLAFENONE