BERLAFENONE

Investigational

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H25NO2
Molecular Weight	299.4073
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC(C)(C)NCC(O)COC1=C(C=CC=C1)C2=CC=CC=C2

InChI

InChIKey=DBHPVKNFKBKJCE-UHFFFAOYSA-N

InChI=1S/C19H25NO2/c1-19(2,3)20-13-16(21)14-22-18-12-8-7-11-17(18)15-9-5-4-6-10-15/h4-12,16,20-21H,13-14H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C19H25NO2
Molecular Weight	299.4073
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description

Berlafenone (previously known as GK 23 G), a sodium channel antagonist was studied as a class Ic antiarrhythmic agent, but development has been discontinued.

Originator

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Sodium channel alpha subunit 72	Blocker 553

PubMed

Show entries

Title	Date	PubMed
Negative inotropic effects of the new class I antiarrhythmic agents berlafenone and alprafenone on electrically stimulated isolated cardiomyocytes.	1992 Mar	1497686

Showing 1 to 1 of 1 entries

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