BERLAFENONE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H25NO2
Molecular Weight	299.4073
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)(C)NCC(O)COC1=C(C=CC=C1)C2=CC=CC=C2

InChI

InChIKey=DBHPVKNFKBKJCE-UHFFFAOYSA-N

InChI=1S/C19H25NO2/c1-19(2,3)20-13-16(21)14-22-18-12-8-7-11-17(18)15-9-5-4-6-10-15/h4-12,16,20-21H,13-14H2,1-3H3

HIDE SMILES / InChI

Molecular Formula	C19H25NO2
Molecular Weight	299.4073
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2590263 | https://adisinsight.springer.com/drugs/800000213

Berlafenone (previously known as GK 23 G), a sodium channel antagonist was studied as a class Ic antiarrhythmic agent, but development has been discontinued.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sodium channel alpha subunit 76 Target ID: CHEMBL2331043 Sources: https://patents.google.com/patent/US20140221286A1/en	Blocker 537

PubMed

Title	Date	PubMed
Electrophysiologic, haemodynamic and antiarrhythmic effects of the new class Ic agent 1-(2'-biphenyloxy)-2-tert.-butylamino-propanol-2-hydrochloride.	1989 Sep	2590263
Negative inotropic effects of the new class I antiarrhythmic agents berlafenone and alprafenone on electrically stimulated isolated cardiomyocytes.	1992 Mar	1497686

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:29:21 GMT 2023` Edited by `admin` on `Fri Dec 15 15:29:21 GMT 2023`
Record UNII	4MYE3XA3GV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BERLAFENONE

Official Name

English

(±)-1-(2-BIPHENYLYLOXY)-3-(TERT-BUTYLAMINO)-2-PROPANOL

Systematic Name

English

berlafenone [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47793