{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
{{facet.count}}
Restrict the search for
angiotensin ii
to a specific field?
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2023)
Source URL:
First approved in 2020
Source:
21 CFR 333A
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Acetophenone is an organic compound with major use in the chemical industry for the polymerization of olefins, and organic synthesis as a photosensitizer and as a specialty solvent for plastics and resins. It is also a chemical intermediate for the odorant ethyl methyl phenylglycidate, the riot control agent 2-chloroacetophenone and 2- bromoacetophenone for dyes. It is used in the manufacture of pharmaceuticals, rubber, dyes, and corrosion inhibitors. Acetophenone was approved by the FDA as a flavoring substance and adjuvant in food. It is used as a flavoring agent in non-alcoholic beverages, ice cream, candy, baked goods, gelatins, puddings, tobacco, and chewing gum. It is used to impart an orange-blossom fragrance in soaps, detergents, creams, lotions, and perfumes.
Status:
Possibly Marketed Outside US
Source:
M013
(2019)
Source URL:
First approved in 2019
Source:
M013
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
First approved in 2019
Source:
21 CFR 348
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Orotic acid is a minor dietary constituent. Historically it was believed to be part of the vitamin B complex and was called vitamin B13, but it is now known that it is not a vitamin and is synthesized in the body, where it arises as an intermediate in the pathway for the synthesis of pyrimidine nucleotides. Orotic acid is converted to UMP by UMP synthase, a multifunctional protein with both orotate phosphoribosyl transferase and orotidylate decarboxylase activity. The most frequently observed inborn error of pyrimidine nucleotide synthesis is a mutation of the multifunctional protein UMP synthase. As a result, plasma orotic acid accumulates to high concentrations, and increased quantities appear in the urine. Orotic acid levels are elevated in the urea cycle defects ornithine transcarbamylase (OTC) deficiency, citrullinemia and argininosuccinic acidemia, as well as the mitochondrial transport disorder hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. Orotic acid is also elevated in hereditary orotic aciduria, or uridine monophosphate synthase deficiency, an autosomal recessive disorder characterized by megaloblastic anemia and crystalluria. In addition, orotic acid in combination with leflunomide is in the phase II of clinical trial to evaluate the clinical efficacy and safety of a combination in kidney transplant patients with high levels of Polyoma BK viruria for the purpose of preventing polyoma BK viremia and nephropathy, that could lead to kidney transplant loss from viral damage, acute rejection or both.
Status:
Possibly Marketed Outside US
Source:
Tai Yu Ling Antibacterial Sprays10mL by Weifang Hongyang Pharmacy Co., Ltd.
(2018)
Source URL:
First approved in 2018
Source:
Tai Yu Ling Antibacterial Sprays10mL by Weifang Hongyang Pharmacy Co., Ltd.
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Matrine is an active alkaloid, extracted from a traditional Chinese herbs of the Sophora family. Matrine has been reported for its anti-inflammatory and neuroprotective effects. It was demonstrated that the antinociceptive effects of ( )-matrine was mediated by mu- and kappa-opioid receptors. It could dose-dependently restore the balance of Th17/Treg cytokines and attenuate the cognitive impairment in Alzheimer's disease rats. Sophora flavescens and its bioactive compound, matrine alleviated caffeine-induced hyperactivity and promoted non-rapid eye movement sleep by activating ventrolateral preoptic nucleus neurons and modulating serotonergic transmission. Clinical trial results indicate, that intramuscular matrine may be an economical, efficacious, safe drug for the treatment of chronic hepatitis B. Matrine injection may be used to protect the liver function for patients with primary hepatic carcinoma after trans-artery chemo-embolization (TAE), to relieve the liver cells damage, and to improve the tolerance of TAE, so as to perform the next TAE in time.
Status:
Possibly Marketed Outside US
Source:
Unknown by I.G. Farbenindustrie
Source URL:
First approved in 2018
Source:
21 CFR 358H
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor, that has been used for psoriasis vulgaris and acne treatment. Tioxolone is reported to possess cytostatic, antipsoriatic, antibacterial and anti-mycotic properties. Tioxolone is also added to some cosmetics (e.g. hair shampoos and skin cleansers), due to claims for its oil-regulating and antibacterial properties.
Status:
Possibly Marketed Outside US
First approved in 2018
Source:
NADA141342
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Alfaxalone is a rapidly acting hydrophobic synthetic neurosteroid. It is indicated for the induction and maintenance of anesthesia and for induction of anesthesia followed by maintenance with an inhalant anesthetic, in cats and dogs. Alfaxalone induces anaesthesia through activity at the gamma amino butyric acid sub-type A receptor (GABAA) present on cells in the Central Nervous System (CNS). Alfaxalone enhances the effects of GABA at the GABAA receptors resulting in opening of channels into the cells and an influx of chloride ions. This causes hyperpolarisation of the cells and inhibition of neural impulse transmission. Alfaxalone can be safely combined with premedicants (xylazine, (dex)medetomidine, acepromazine, midazolam), opioids (morphine, methadone, hydromorphone, butorphanol, nalbuphine, buprenorphine, fentanyl), and NSAIDs. Alfaxalone’s adverse reactions are: hypotension, tachycardia, apnea, hypertension, bradypnea and others.
Status:
Possibly Marketed Outside US
Source:
SpaGelpatch 42degrees celsius CORSET by SENNY STUDIO Co., Ltd
(2017)
Source URL:
First approved in 2017
Source:
SpaGelpatch 42degrees celsius CORSET by SENNY STUDIO Co., Ltd
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Cordycepin, or 3'-deoxyadenosine, is a derivative of the nucleoside adenosine, differing from the latter by the absence of the hydroxy group in the 3' position of its ribose part. Cytostatic effect of cordycepin is due to incorporation of phospho-cordycepin into mRNA and inhibition of mRNA synthesis. Cordycepin exhibit rapid antidepressant effect due to potentiation of AMPA receptors
Status:
Possibly Marketed Outside US
First approved in 2017
Source:
M020
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Cinnamic acid is a polyphenol found in cinnamon oil and used in commercial flavorings. Recent studies have shown the pharmacological properties of cinnamic acid and its derivatives, including hepatoprotective, anti-oxidant, and anti-diabetic activities. In preclinical studies cinnamic acid demonstrated to be a promising candidate for the treatment ob obesity and diabetes. The mechanism of action of cinnamic acid in obesity is explained by its ability to inhibit lipases and ACE (angiotensin-converting enzyme). However, there are several hypotesis regarding the effect of cinnamic acid in diabetes: cinnamic acid enhances glucose-induced insulin secretion, prevents palmitic acid-induced lipotoxicity, inhibits palmitic acid-induced alteration of lipogenic gene and protein expression (AMPK, SREBP-1c, FAS, ACC), inhibits DPP IV, exhibits an additive effect on the uptake of glucose, stimulates adiponectin secretion, etc.
Status:
Possibly Marketed Outside US
Source:
21 CFR 352
(2018)
Source URL:
First approved in 2017
Source:
21 CFR 352
Source URL:
Class (Stereo):
CHEMICAL (EPIMERIC)
Propylene Glycol Ricinoleate is an ester of propylene glycol and ricinoleic acid. Clear, pale, moderately viscous liquid emollient derived from castor oil. Because it forms occlusive barriers, it reduces transepidermal water loss, and also hydrates the skin through humectancy via hydrogen bonding between water and the material’s hydroxyl groups, being able to attract and bind water from the atmosphere and lower layers of the epidermis and dermis. It can be used in color cosmetics, AP/DEO, lipsticks, sun care, lip balms, shave products, creamy cleansers, creams and lotions, massage oils, lip treatments.
Status:
Possibly Marketed Outside US
Source:
ANDA076498
(2017)
Source URL:
First approved in 2017
Source:
ANDA076498
Source URL:
Class (Stereo):
CHEMICAL (MIXED)
HYDROXYOCTACOSANYL HYDROXYSTEARATE is an inactive component of REFISSA® (tretinoin cream, 0.05%), which is indicated as an adjunctive agent for use in the mitigation (palliation) of fine wrinkles, mottled hyperpigmentation, and tactile roughness of facial skin in patients who do not achieve such palliation using comprehensive skin care and sun avoidance programs.
