U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C7H4O3S
Molecular Weight 168.17
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIOXOLONE

SMILES

OC1=CC=C2SC(=O)OC2=C1

InChI

InChIKey=SLYPOVJCSQHITR-UHFFFAOYSA-N
InChI=1S/C7H4O3S/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3,8H

HIDE SMILES / InChI

Description
Curator's Comment: The description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/153995 | https://www.ncbi.nlm.nih.gov/pubmed/4989743 |

Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor, that has been used for psoriasis vulgaris and acne treatment. Tioxolone is reported to possess cytostatic, antipsoriatic, antibacterial and anti-mycotic properties. Tioxolone is also added to some cosmetics (e.g. hair shampoos and skin cleansers), due to claims for its oil-regulating and antibacterial properties.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
0.091 µM [Ki]
1.77 µM [IC50]
6.56 µM [Ki]
4.93 µM [Ki]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown

Approved Use

Unknown
Primary
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
The supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one (tioxolone).
2004 Jun
Inhibition profiling of human carbonic anhydrase II by high-throughput screening of structurally diverse, biologically active compounds.
2006 Oct
Patents

Sample Use Guides

Recomended doses in cosmetics: Tioxolone Powder: 0.1 -0.5%; Tioxolone 5% Water Soluble: 2-10%
Route of Administration: Topical
In Vitro Use Guide
Unknown
Name Type Language
TIOXOLONE
INCI   INN   MART.   MI   WHO-DD  
INN   INCI  
Official Name English
TIOXOLONE [INCI]
Common Name English
tioxolone [INN]
Common Name English
TIOXOLONE [MI]
Common Name English
TIOXOLONE [MART.]
Common Name English
NSC-758240
Code English
Tioxolone [WHO-DD]
Common Name English
Classification Tree Code System Code
WHO-VATC QD10AB03
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
NCI_THESAURUS C29700
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
WHO-ATC D10AB03
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
Code System Code Type Description
MESH
C009474
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
PUBCHEM
72139
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
INN
2002
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
CAS
4991-65-5
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
SMS_ID
100000077258
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
ChEMBL
CHEMBL442687
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PRIMARY
MERCK INDEX
m10882
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY Merck Index
NSC
758240
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
ECHA (EC/EINECS)
225-653-0
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
WIKIPEDIA
TIOXOLONE
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
EVMPD
SUB11100MIG
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
EPA CompTox
DTXSID5045885
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
FDA UNII
S0FAJ1R9CD
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
DRUG BANK
DB13343
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
DAILYMED
S0FAJ1R9CD
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
DRUG CENTRAL
3607
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
NCI_THESAURUS
C76521
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
CHEBI
568021
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY
RXCUI
2059173
Created by admin on Fri Dec 15 15:45:57 GMT 2023 , Edited by admin on Fri Dec 15 15:45:57 GMT 2023
PRIMARY