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Details

Stereochemistry ACHIRAL
Molecular Formula C7H4O3S
Molecular Weight 168.17
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of TIOXOLONE

SMILES

OC1=CC=C2SC(=O)OC2=C1

InChI

InChIKey=SLYPOVJCSQHITR-UHFFFAOYSA-N
InChI=1S/C7H4O3S/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3,8H

HIDE SMILES / InChI

Molecular Formula C7H4O3S
Molecular Weight 168.17
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Tioxolone is a metalloenzyme carbonic anhydrase I inhibitor, that has been used for psoriasis vulgaris and acne treatment. Tioxolone is reported to possess cytostatic, antipsoriatic, antibacterial and anti-mycotic properties. Tioxolone is also added to some cosmetics (e.g. hair shampoos and skin cleansers), due to claims for its oil-regulating and antibacterial properties.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
0.091 µM [Ki]
1.77 µM [IC50]
6.56 µM [Ki]
4.93 µM [Ki]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Recomended doses in cosmetics: Tioxolone Powder: 0.1 -0.5%; Tioxolone 5% Water Soluble: 2-10%
Route of Administration: Topical
In Vitro Use Guide
Unknown
Substance Class Chemical
Record UNII
S0FAJ1R9CD
Record Status Validated (UNII)
Record Version