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Details

Stereochemistry ABSOLUTE
Molecular Formula C10H13N5O3
Molecular Weight 251.2419
Optical Activity UNSPECIFIED
Defined Stereocenters 3 / 3
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CORDYCEPIN

SMILES

NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](CO)C[C@H]3O

InChI

InChIKey=OFEZSBMBBKLLBJ-BAJZRUMYSA-N
InChI=1S/C10H13N5O3/c11-8-7-9(13-3-12-8)15(4-14-7)10-6(17)1-5(2-16)18-10/h3-6,10,16-17H,1-2H2,(H2,11,12,13)/t5-,6+,10+/m0/s1

HIDE SMILES / InChI

Description

Cordycepin, or 3'-deoxyadenosine, is a derivative of the nucleoside adenosine, differing from the latter by the absence of the hydroxy group in the 3' position of its ribose part. Cytostatic effect of cordycepin is due to incorporation of phospho-cordycepin into mRNA and inhibition of mRNA synthesis. Cordycepin exhibit rapid antidepressant effect due to potentiation of AMPA receptors

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
50.0 µM [Ki]
21.0 µM [IC50]

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Unknown
Primary
Unknown

PubMed

Sample Use Guides

In Vivo Use Guide
Cordycepin is administred via IV infusions at escalating doses starting from 6mg/m2
Route of Administration: Intravenous
In Vitro Use Guide
Cytotoxicity of cordycepin was measured using standard MTT assay on TdT-positive leukemia cell lines (NALM-6, MOLT-4, CEM). Cells were pre-incubated with 2.5 uM deoxycoformycin for 30 min and treated with cordycepin. IC50 is 0.18-0.9 uM.