U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 161 - 170 of 190 results

Diallyl disulfide (DADS) or allyl disulfide is the main organosulfur ingredient in garlic, with known antioxidant and anti-inflammatory activities. It has been shown to have multi-targeted antitumor activities in a variety of cancer cells Experiments in vitro have revealed, that diallyl disulfide inhibits the metastasis of type Ⅱ esophageal-gastric junction adenocarcinoma cells via NF-κB and PI3K/AKT signaling pathways. At the same time, was shown the drug suppresses cell stemness, proliferation, metastasis and glucose metabolism in breast cancer stem cells partly through the inhibition of CD44/PKM2/AMPK. Besides diallyl disulfide can be a promising agent for the treatment of emphysema, this was discovered in experiments on rats. And also drug shows protective effects against acetaminophen (AAP)-induced acute hepatotoxicity.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Molybdenum Disulfide is the inorganic Molybdenum salt often used in dry lubricants and in petroleum refining. Its semiconducting ability and similarity to the carbon-based graphene make molybdenum disulfide of interest to scientists as a possible candidate for use in the manufacture of electronics. Molybdenum Disulfide is often a component of blends and composites that require low friction. For example, it is added to graphite to improve sticking. Molybdenum Disulfide is employed as a cocatalyst for desulfurization in petrochemistry, for example, hydrodesulfurization. The effectiveness of the Molybdenum Disulfide catalysts is enhanced by doping with small amounts of cobalt or nickel. The intimate mixture of these sulfides is supported on alumina. Such catalysts are generated in situ by treating molybdate/cobalt or nickel-impregnated alumina with H2S or an equivalent reagent.
Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Other

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
US Approved Allergenic Extract (1994)

Class (Stereo):
CHEMICAL (ACHIRAL)



Dipentamethylenethiuram disulfide is an accelerator and vulcanizing agent used in the rubber industry. It can be found in latex gloves and other rubber products found in homes and offices. Dipentamethylenethiuram disulfide is a standardized chemical allergen. The physiologic effect of dipentamethylenethiuram disulfide is by means of increased histamine release, and cell-mediated Immunity. The chemical classification of dipentamethylenethiuram disulfide is allergens. It is used for diagnosis of contact allergy. It is a component of Thiuram Mix, used in the epicutaneous patch test, called T.R.U.E. TEST, approved by FDA in 1994. T.R.U.E. TEST is indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Showing 161 - 170 of 190 results