DIPENTAMETHYLENETHIURAM DISULFIDE

US Approved Allergenic Extract (1994)

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H20N2S4
Molecular Weight	320.561
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of DIPENTAMETHYLENETHIURAM DISULFIDE

Structure Search

SMILES

S=C(SSC(=S)N1CCCCC1)N2CCCCC2

InChI

InChIKey=KNBRWWCHBRQLNY-UHFFFAOYSA-N

InChI=1S/C12H20N2S4/c15-11(13-7-3-1-4-8-13)17-18-12(16)14-9-5-2-6-10-14/h1-10H2

HIDE SMILES / InChI

Description
Sources: http://www.fda.gov/downloads/BiologicsBloodVaccines/Allergenics/UCM294327.pdf
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/spl/data/401b27b4-3e75-4f91-83f5-f8f39502b986/401b27b4-3e75-4f91-83f5-f8f39502b986.xml and http://www.dormer.com/Allergens/PDF/MSDS/D-019.pdf

Dipentamethylenethiuram disulfide is an accelerator and vulcanizing agent used in the rubber industry. It can be found in latex gloves and other rubber products found in homes and offices. Dipentamethylenethiuram disulfide is a standardized chemical allergen. The physiologic effect of dipentamethylenethiuram disulfide is by means of increased histamine release, and cell-mediated Immunity. The chemical classification of dipentamethylenethiuram disulfide is allergens. It is used for diagnosis of contact allergy. It is a component of Thiuram Mix, used in the epicutaneous patch test, called T.R.U.E. TEST, approved by FDA in 1994. T.R.U.E. TEST is indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
S. cerevislae growth 1 Target ID: S. cerevislae growth Sources: http://www.ncbi.nlm.nih.gov/pubmed/9873584	Inhibitor 8297
C. albicans growth 3 Target ID: C. albicans growth Sources: http://www.ncbi.nlm.nih.gov/pubmed/9873584	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Allergic contact dermatitis 14 Sources: http://www.fda.gov/downloads/BiologicsBloodVaccines/Allergenics/UCM294327.pdf	Diagnostic		Approved 8429	T.R.U.E. TEST Approved Use T.R.U.E. TEST is an epicutaneous patch test indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels. Launch Date 1993

PubMed

Title	Date	PubMed
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.	1996 Sep 13	8809151

Patents

Sample Use Guides

In Vivo Use Guide

Apply the three adhesive panels of allergens and allergen mixes on healthy skin of the back. Remove panels and evaluate the skin 48 hours after application. Re-evaluate the skin 72 to 96 hours after application.

Route of Administration: Topical

In Vitro Use Guide

MIC against S. cerevislae and C. albicans 1.6 - 2 ug/mL

Name

Type

Language

DIPENTAMETHYLENETHIURAM DISULFIDE

Common Name

English

NSC-527035

Code

English

DICYCLOPENTAMETHYLENETHIURAM DISULFIDE

Common Name

English

DIPENTAMETHYLENETHIURAM DISULPHIDE

Common Name

English

BIS(PENTAMETHYLENE)THIURAM DISULFIDE

Common Name

English

DICYCLOPENTAMETHYLENETHIURAM DISULPHIDE

Common Name

English

BIS(1-PIPERIDYLTHIOCARBONYL)DISULFIDE

Systematic Name

English

METHANETHIONE, 1,1'-DITHIOBIS(1-(1-PIPERIDINYL)-

Systematic Name

English

Classification Tree Code System Code

NDF-RT

N0000185508