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Details

Stereochemistry ACHIRAL
Molecular Formula C12H20N2S4
Molecular Weight 320.561
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIPENTAMETHYLENETHIURAM DISULFIDE

SMILES

S=C(SSC(=S)N1CCCCC1)N2CCCCC2

InChI

InChIKey=KNBRWWCHBRQLNY-UHFFFAOYSA-N
InChI=1S/C12H20N2S4/c15-11(13-7-3-1-4-8-13)17-18-12(16)14-9-5-2-6-10-14/h1-10H2

HIDE SMILES / InChI

Description
Curator's Comment: Description was created based on several sources, including http://www.accessdata.fda.gov/spl/data/401b27b4-3e75-4f91-83f5-f8f39502b986/401b27b4-3e75-4f91-83f5-f8f39502b986.xml and http://www.dormer.com/Allergens/PDF/MSDS/D-019.pdf

Dipentamethylenethiuram disulfide is an accelerator and vulcanizing agent used in the rubber industry. It can be found in latex gloves and other rubber products found in homes and offices. Dipentamethylenethiuram disulfide is a standardized chemical allergen. The physiologic effect of dipentamethylenethiuram disulfide is by means of increased histamine release, and cell-mediated Immunity. The chemical classification of dipentamethylenethiuram disulfide is allergens. It is used for diagnosis of contact allergy. It is a component of Thiuram Mix, used in the epicutaneous patch test, called T.R.U.E. TEST, approved by FDA in 1994. T.R.U.E. TEST is indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Target ID: S. cerevislae growth
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
T.R.U.E. TEST

Approved Use

T.R.U.E. TEST is an epicutaneous patch test indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Launch Date

7.5729601E11
PubMed

PubMed

TitleDatePubMed
Evaluation of selected chemotypes in coupled cellular and molecular target-based screens identifies novel HIV-1 zinc finger inhibitors.
1996 Sep 13
Patents

Sample Use Guides

Apply the three adhesive panels of allergens and allergen mixes on healthy skin of the back. Remove panels and evaluate the skin 48 hours after application. Re-evaluate the skin 72 to 96 hours after application.
Route of Administration: Topical
In Vitro Use Guide
MIC against S. cerevislae and C. albicans 1.6 - 2 ug/mL
Name Type Language
DIPENTAMETHYLENETHIURAM DISULFIDE
Common Name English
NSC-527035
Code English
DICYCLOPENTAMETHYLENETHIURAM DISULFIDE
Common Name English
DIPENTAMETHYLENETHIURAM DISULPHIDE
Common Name English
BIS(PENTAMETHYLENE)THIURAM DISULFIDE
Common Name English
DICYCLOPENTAMETHYLENETHIURAM DISULPHIDE
Common Name English
BIS(1-PIPERIDYLTHIOCARBONYL)DISULFIDE
Systematic Name English
METHANETHIONE, 1,1'-DITHIOBIS(1-(1-PIPERIDINYL)-
Systematic Name English
Classification Tree Code System Code
NDF-RT N0000185508
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
Code System Code Type Description
FDA UNII
CR113982E5
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY
EPA CompTox
DTXSID4048727
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY
SMS_ID
100000134277
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY
EVMPD
SUB61036
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY
NSC
527035
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY
NDF-RT
N0000171131
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY Allergens [Chemical/Ingredient]
NDF-RT
N0000175629
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY Increased Histamine Release [PE]
ECHA (EC/EINECS)
202-328-1
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY
RXCUI
1426773
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY RxNorm
PUBCHEM
7188
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY
NDF-RT
N0000184306
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY Cell-mediated Immunity [PE]
CAS
94-37-1
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY
DAILYMED
CR113982E5
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY
DRUG BANK
DB14174
Created by admin on Fri Dec 15 17:40:17 UTC 2023 , Edited by admin on Fri Dec 15 17:40:17 UTC 2023
PRIMARY