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Details

Stereochemistry ACHIRAL
Molecular Formula C12H20N2S4
Molecular Weight 320.561
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIPENTAMETHYLENETHIURAM DISULFIDE

SMILES

S=C(SSC(=S)N1CCCCC1)N2CCCCC2

InChI

InChIKey=KNBRWWCHBRQLNY-UHFFFAOYSA-N
InChI=1S/C12H20N2S4/c15-11(13-7-3-1-4-8-13)17-18-12(16)14-9-5-2-6-10-14/h1-10H2

HIDE SMILES / InChI

Molecular Formula C12H20N2S4
Molecular Weight 320.561
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Dipentamethylenethiuram disulfide is an accelerator and vulcanizing agent used in the rubber industry. It can be found in latex gloves and other rubber products found in homes and offices. Dipentamethylenethiuram disulfide is a standardized chemical allergen. The physiologic effect of dipentamethylenethiuram disulfide is by means of increased histamine release, and cell-mediated Immunity. The chemical classification of dipentamethylenethiuram disulfide is allergens. It is used for diagnosis of contact allergy. It is a component of Thiuram Mix, used in the epicutaneous patch test, called T.R.U.E. TEST, approved by FDA in 1994. T.R.U.E. TEST is indicated for use as an aid in the diagnosis of allergic contact dermatitis in persons 18 years of age and older whose history suggests sensitivity to one or more of the 35 substances included on the T.R.U.E. TEST panels.

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
T.R.U.E. TEST

PubMed

Sample Use Guides

In Vivo Use Guide
Apply the three adhesive panels of allergens and allergen mixes on healthy skin of the back. Remove panels and evaluate the skin 48 hours after application. Re-evaluate the skin 72 to 96 hours after application.
Route of Administration: Topical
In Vitro Use Guide
MIC against S. cerevislae and C. albicans 1.6 - 2 ug/mL
Substance Class Chemical
Record UNII
CR113982E5
Record Status Validated (UNII)
Record Version