U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 15981 - 15990 of 16236 results

Status:
Possibly Marketed Outside US
Source:
Octinum-D by Knoll
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Conditions:

Octamylamine is an Antispasmodic. Trademark: Octinum D.
Status:
Possibly Marketed Outside US
Source:
NCT02495324: Phase 4 Interventional Completed Essential,Hypertension
(2015)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Fimasartan is a angiotensin II receptor antagonist which was developed in Korea for the treatment of hypertension. The drug is available in different forms: Kanarb, Dukarb (in combination with Amlodipine), Tuvero (in combination with Rosuvastatin). Fimasartan was tested to be effective in Mexican and Russian population and now is being tested in the USA.
Status:
Possibly Marketed Outside US
Source:
CFR:21 CFR 331.11
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Mesotartaric acid is one of an isomer of Tartaric acid. Mesotartaric acid is a diastereomer which has two opposite chiral centers in the same molecule making the molecule optically inactive. Mesotartaric acid is also commonly called pyrotartaric acid because it is formed by heating d-(-)-tartaric acid. Mesotartaric Acid have several industrial application and may be used as pH regulator, a metal chelator, the reagent in organic synthesis and etc.
Status:
Possibly Marketed Outside US
Source:
Neonon by Eggleton, P.|Eggleton, G.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Phosphocreatine (creatine phosphate, PCr, PC) is the phosphorylated form of endogenous creatine that serves as a rapidly mobilizable reserve of high-energy phosphates in skeletal muscle and the brain of vertebrates. Phosphocreatine is a key component in the intracellular system of energy buffering and transports from the site of energy production to the site of energy utilization to ensure that supply meets the high and dynamic demands of the heart. Phosphocreatine can anaerobically donate a phosphate group to ADP to form ATP during the first two to seven seconds following an intense muscular or neuronal effort. Conversely, excess ATP can be used during a period of low effort to convert creatine to phosphocreatine. The reversible phosphorylation of creatine is catalyzed by several creatine kinases. Particularly, PCr makes the energy of phosphoryl bonds of adenosine triphosphate (ATP) available at the myofibrillar creatine kinase that allows myocardium contraction. Supplementation with PCr was, therefore, suggested as potentially beneficial in patients with acute and chronic myocardial ischaemic injury. Phosphocreatine has been tried in the treatment of cardiac disorders and has been added to cardioplegic solutions. Phosphocreatine is used intravenously in hospitals in some parts of the world for cardiovascular problems under the name Neoton and also used by some professional athletes, as it is not a controlled substance.
Sodium 1-Naphthaleneacetate (SODIUM 1-NAPHTHALENEACETATE) is a plant growth regulator. It has being shown that root application of certain concentration of sodium naphthalene acetate (SNA) could promote the growth of tomato seedlings by increasing the tomato root activity, protective enzymes activity, Pn and regulating endogenous hormone concentration under suboptimum temperature and light condition.
Status:
Possibly Marketed Outside US
Source:
SULINDAC by Fillet, M.|Hubert, P.|Crommen, J.
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



(R)-Sulindac is the (R)-enantiomer of nonsteroidal anti-inflammatory drug (NSAID) Sulindac, that is marketed in the U.S. by Merck as Clinoril. Sulindac is a prodrug, derived from sulfinylindene, that is converted in vivo to an active sulfide compound by liver methionine sulfoxide reductases (Msr). The (Msr) family of enzymes includes two major classes, MsrA and MsrB, that specifically reduce the S- and R-epimers of Sulindac. Reduction of (R)-Sulindac to Sulindac Sulfide catalyzed by methionine sulfoxide reductase (Msr)-B. The oxidation of both epimers to sulindac sulfone is catalyzed primarily by the microsomal cytochrome P450 (P450) system. (S)-Sulindac increases the activity of the P450 system better than (R)-sulindac, but both epimers increase primarily the enzymes that oxidize (R)-sulindac. Both epimers can protect normal lung cells against oxidative damage and enhance the killing of lung cancer cells exposed to oxidative stress.
Status:
Possibly Marketed Outside US
Source:
INAVIR by Daiichi Sankyo
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Laninamivir ocatanoate is a prodrug of Laninamivir (R-125489), a new neuraminidase (NA) inhibitor, was discovered, and in this study, its NA inhibitory activities against various influenza viruses including oseltamivir-resistant viruses are reported. Laninamivir octanoate has been approved for use in Japanese clinics for the treatment and prevention of influenza in both adults and children. The inhaled laninamivir octanoate is converted into its active form, laninamivir, in the lungs where a high concentration persists for a long period of time.
Status:
Possibly Marketed Outside US
Source:
Japan:Pibutidine Hydrochloride
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Pibutidine hydrochloride (IT-066), a novel histamine H2 receptor antagonist has powerful and long lasting antisecretory and antiulcer effects and is a useful antisecretory drug for treatment of peptic ulcer diseases.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Pipethanate ethobromide is an antimuscarinic with actions similar to those of atropine. It has been used in the symptomatic treatment of visceral spasms in oral doses of up to 160 mg daily in divided doses. Pipethanate ethobromide has also been given intramuscularly or intravenously in doses of 10 to 20 mg daily and rectally in doses of 60 or 120 mg daily.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Morclofon is an antitussive agent.

Showing 15981 - 15990 of 16236 results