U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 158741 - 158750 of 167129 results

Status:
US Previously Marketed
Source:
Cerium Oxalate U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Cerium Oxalate U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Cerous iodide is a salt of lanthanide metal cerium (III) and iodide ion. In 1920s solution of cerous iodide for intravenous injection (called "introcid") was used as an antimicrobial agent for treating puerperal fever. It has shown prophylactic activity against sepsis, and was explored for its antineoplastic properties in patients with lymphogranulomatosis or inoperable solid tumors. According to the clinical reports, it has been applied with remarkable benefit, as indicated by tumor shrinkage and improved quality of life in several cases of locally advanced or metastatic tumors of different origin.
Status:
US Previously Marketed
Source:
Chromium Trioxide U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Chromium Trioxide U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
US Previously Marketed
Source:
Strontium Bromide U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Strontium Bromide U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Conditions:

Strontium ranelate is composed of an organic moiety (ranelic acid) and of two atoms of stable nonradioactive strontium. In vitro, strontium ranelate increases collagen and noncollagenic proteins synthesis by mature osteoblast enriched cells. The effects of strontium ranelate on bone formation were confirmed as strontium ranelate enhanced pre-osteoblastic cell replication. The stimulation by strontium ranelate of the replication of osteoprogenitor cell and collagen, as well as noncollagenic protein synthesis in osteoblasts, provides substantial evidence to categorize strontium ranelate as a bone-forming agent. In the isolated rat osteoclast assay, a pre-incubation of bone slices with strontium ranelate induced a dose- dependent inhibition of the bone resorbing activity of treated rat osteoclast. Strontium ranelate also dose-dependently inhibited, in a chicken bone marrow culture, the expression of both carbonic anhydrase II and the alpha-subunit of the vitronectin receptor. These effects showing that strontium ranelate significantly affects bone resorption due to a direct and/or matrix-mediated inhibition of osteoclast activity and also inhibits osteoclasts differentiation, are compatible with the profile of an anti-resorptive drug. Pharmacological and clinical studies suggest that strontium ranelate optimizes bone resorption and bone formation, resulting in increased bone mass, which may be of great value in the treatment of osteoporosis. Strontium ranelate is approved by EMA for the treatment of severe osteoporosis in postmenopausal women and in adult men.
Status:
US Previously Marketed
Source:
Corrosive Mercuric Chloride U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Corrosive Mercuric Chloride U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Potassium Triiodomercurate(II) is a periodometallate salt. It contains a triiodomercurate(1-). It is an antiseptic (topical) and disinfectant. It is also an antiseborrheic agent.
Status:
US Previously Marketed
Source:
Bromauric Acid N. F.
(1921)
Source URL:
First marketed in 1921
Source:
Bromauric Acid N. F.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Gold trichloride is used as a catalyst in synthesis of new compounds. It was shown that gold trichloride was not the marker of contact allergy and could not be recommended in patch testing.
Status:
US Previously Marketed
Source:
Corrosive Mercuric Chloride U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Corrosive Mercuric Chloride U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Potassium Triiodomercurate(II) is a periodometallate salt. It contains a triiodomercurate(1-). It is an antiseptic (topical) and disinfectant. It is also an antiseborrheic agent.
Status:
US Previously Marketed
Source:
Bromauric Acid N. F.
(1921)
Source URL:
First marketed in 1921
Source:
Bromauric Acid N. F.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Gold trichloride is used as a catalyst in synthesis of new compounds. It was shown that gold trichloride was not the marker of contact allergy and could not be recommended in patch testing.
Status:
US Previously Marketed
Source:
Antimony Oxide N.F.
(1921)
Source URL:
First marketed in 1921
Source:
Antimony Oxide N.F.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Stibophen (Fuadin), an organic trivalent antimony compound, has been used for many years in the treatment of schistosomiasis. Stibophen is used as treatment of schistosomiasis by intramuscular injection. Stibophen is known to act by selectively inhibiting worm PFK.
Status:
US Previously Marketed
Source:
sodium molybdate
(1921)
Source URL:
First marketed in 1921
Source:
sodium molybdate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Molybdic acid refers to hydrated forms of molybdenum trioxide. There is no information related to the biological and pharmacological application of molybdic acid. It is known, that this substance is used as heterogeneous catalysts.
Status:
US Previously Marketed
Source:
Cerium Oxalate U.S.P.
(1921)
Source URL:
First marketed in 1921
Source:
Cerium Oxalate U.S.P.
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Cerous iodide is a salt of lanthanide metal cerium (III) and iodide ion. In 1920s solution of cerous iodide for intravenous injection (called "introcid") was used as an antimicrobial agent for treating puerperal fever. It has shown prophylactic activity against sepsis, and was explored for its antineoplastic properties in patients with lymphogranulomatosis or inoperable solid tumors. According to the clinical reports, it has been applied with remarkable benefit, as indicated by tumor shrinkage and improved quality of life in several cases of locally advanced or metastatic tumors of different origin.

Showing 158741 - 158750 of 167129 results