STIBINE

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Sb.3H
Molecular Weight	124.784
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H-].[H-].[H-].[Sb+3]

InChI

InChIKey=OPKZYVWQBWSDDB-UHFFFAOYSA-N

InChI=1S/Sb.3H/q+3;3*-1

HIDE SMILES / InChI

Molecular Formula	H
Molecular Weight	1.0079
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Sb
Molecular Weight	121.76
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.whocc.no/atcvet/atcvet_index/?code=QR05CA07https://www.ncbi.nlm.nih.gov/pubmed/5295139 | https://www.ncbi.nlm.nih.gov/pubmed/14851220 | https://www.ncbi.nlm.nih.gov/pubmed/8898332
Curator's Comment: description was created based on several sources, including https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7ef48d40-6d63-440b-a73c-46d89f425936

Stibophen (Fuadin), an organic trivalent antimony compound, has been used for many years in the treatment of schistosomiasis. Stibophen is used as treatment of schistosomiasis by intramuscular injection. Stibophen is known to act by selectively inhibiting worm PFK.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
ATP-dependent 6-phosphofructokinase 21 Target ID: Q27778 Gene ID: NA Gene Symbol: PFK Target Organism: Schistosoma mansoni (Blood fluke) Sources: https://www.ncbi.nlm.nih.gov/pubmed/8898332 \| https://www.ncbi.nlm.nih.gov/pubmed/13446367	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Schistosomiasis 32 Sources: https://www.ncbi.nlm.nih.gov/pubmed/193200 https://www.ncbi.nlm.nih.gov/pubmed/193201 https://www.ncbi.nlm.nih.gov/pubmed/13268811 https://www.ncbi.nlm.nih.gov/pubmed/20292219	Curative		Approved 8429	Fuadin Approved Use Schistosomiasis
Unknown 2578

PubMed

Title	Date	PubMed
Evaluation of fuadin therapy in schistosomiasis japonica.	1951 Apr	14851220
Laboratory studies on the joint effects of certain tris (p-aminophenyl) carbonium salts and antimonials as antischistosomal drugs.	1965	5295139
Current chemotherapy of schistosomiasis japonica in the Philippines.	1976 Jun	193200
[Substantiation of maximum permissible levels of antimony trioxide and pentasulide in the atmospheric air of inhabitated places].	1989 Apr	2744535
Purification, kinetics and inhibition by antimonials of recombinant phosphofructokinase from Schistosoma mansoni.	1996 Oct 30	8898332
Antimony impairs nucleotide excision repair: XPA and XPE as potential molecular targets.	2010 Jul 19	20509621
Investigation on the pharmacological profile of 2,6-diacetylpyridine bis(benzoylhydrazone) derivatives and their antimony(III) and bismuth(III) complexes.	2012 Jul	22520151

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 03:29:26 GMT 2023` Edited by `admin` on `Sat Dec 16 03:29:26 GMT 2023`
Record UNII	0VKZ97K3UB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

STIBINE

Systematic Name

English

HYDROGEN ANTIMONIDE

Common Name

English

STIBINE [MI]

Common Name

English

ANTIMONY TRIHYDRIDE

Common Name

English

ANTIMONY HYDRIDE

Systematic Name

English

Code System Code Type Description

HSDB

785