6-Ketoprostaglandin F1alpha (6-keto PGF1a) is a stable hydrolysis product of prostacyclin (PGI2). Due to the short half-life of PGI2, the production of prostacyclin is typically monitored by measurement of the 6-keto-PGF1a metabolite. 6-keto prostaglandin F1α is measured in patients with chronic pulmonary heart disease, where its level was significantly lowered compared with normal controls.

COMPOUND401 is the reversible and selective inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR) (IC50 values are 0.28 and 5.3 μM respectively). COMPOUND401 exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Compound401 has been shown to induce apoptosis and inhibit FRAP-dependent growth in TSC1-/- murine embryo fibroblasts.