6-KETOPROSTAGLANDIN F1.ALPHA.

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H34O6
Molecular Weight	370.4804
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of 6-KETOPROSTAGLANDIN F1.ALPHA.

Structure Search

SMILES

CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1CC(=O)CCCCC(O)=O

InChI

InChIKey=KFGOFTHODYBSGM-ZUNNJUQCSA-N

InChI=1S/C20H34O6/c1-2-3-4-7-14(21)10-11-16-17(19(24)13-18(16)23)12-15(22)8-5-6-9-20(25)26/h10-11,14,16-19,21,23-24H,2-9,12-13H2,1H3,(H,25,26)/b11-10+/t14-,16+,17+,18+,19-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H34O6
Molecular Weight	370.4804
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	1
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6813105 | https://www.ncbi.nlm.nih.gov/pubmed/20584647

6-Ketoprostaglandin F1alpha (6-keto PGF1a) is a stable hydrolysis product of prostacyclin (PGI2). Due to the short half-life of PGI2, the production of prostacyclin is typically monitored by measurement of the 6-keto-PGF1a metabolite. 6-keto prostaglandin F1α is measured in patients with chronic pulmonary heart disease, where its level was significantly lowered compared with normal controls.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Chronic pulmonary heart disease 1 Sources: https://www.ncbi.nlm.nih.gov/pubmed/20584647	Diagnostic		Natural Metabolite	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Decreased in vitro production of 6-keto-prostaglandin F1 alpha by uterine arteries from postmenopausal women.	1989-12	2603925
Production of 6-keto-prostaglandin F1 alpha by rat granulosa cells in vitro.	1982-11	6813105

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 21:55:02 GMT 2025` Edited by `admin` on `Mon Mar 31 21:55:02 GMT 2025`
Record UNII	8URB805JJJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

6-KETOPROSTAGLANDIN F1.ALPHA.

Common Name

English

EPOPROSTENOL RELATED COMPOUND A

Preferred Name

English

6-KETO-PGF1.ALPHA.

Common Name

English

PROST-13-EN-1-OIC ACID, 9,11,15-TRIHYDROXY-6-OXO-, (9.ALPHA.,11.ALPHA.,13E,15S)-

Systematic Name

English

EPOPROSTENOL RELATED COMPOUND A [USP-RS]

Common Name

English

6-OXOPROSTAGLANDIN F1ALPHA

Common Name

English

6-OXO-PGF1.ALPHA.

Common Name

English

Code System Code Type Description

EPA CompTox

DTXSID001317937