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Status:
Investigational
Source:
INN:narazaciclib [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
ON-123300 is a potent and multi-targeted kinase inhibitor with potential application for brain tumor chemotherapy. ON123300 strongly inhibits Ark5 and CDK4, as well as growth factor receptor tyrosine kinases such as β-type platelet-derived growth factor receptor (PDGFRβ). ON123300 inhibited U87 glioma cell proliferation and reduced phosphorylation of Akt, yet it also unexpectedly induced Erk activation, both in a dose- and time-dependent manner that subsequently was attributed to relieving Akt-mediated C-Raf S259 inactivation and activating a p70S6K-initiated PI3K-negative feedback loop. ON123300 demonstrated high brain and brain tumor accumulation and favorable pharmacokinetic characteristics.
Status:
Investigational
Source:
INN:brexanolone caprilcerbate [INN]
Source URL:
Class (Stereo):
CHEMICAL (EPIMERIC)
Status:
Investigational
Source:
NCT03439124: Phase 3 Interventional Completed Community-acquired Pneumonia (CAP)
(2017)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
INN:alizulatide vixocianine [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
INN:copper (<sup>64</sup>Cu) adarulatide tetraxetan [INN]
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Class (Stereo):
CHEMICAL (ACHIRAL)
ITAMELINE, a tetrahydropyridine-oxime, is a long-lasting cholinomimetic agent. It is cleaved in vivo to form an active metabolite, RU 35963, a muscarinic receptor agonist that is nonselective with respect to receptor subtypes.
Status:
Investigational
Source:
INN:soxataltinib [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Investigational
Source:
NCT03447990: Phase 1/Phase 2 Interventional Completed Heart Failure With Reduced Ejection Fraction
(2018)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Investigational
Source:
INN:asandeutertinib [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
