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Details

Stereochemistry ACHIRAL
Molecular Formula C7H12N2O
Molecular Weight 140.183
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of RU-35963

SMILES

CO\N=C\C1=CCCNC1

InChI

InChIKey=YIQBHPFHKPIDSO-RMKNXTFCSA-N
InChI=1S/C7H12N2O/c1-10-9-6-7-3-2-4-8-5-7/h3,6,8H,2,4-5H2,1H3/b9-6+

HIDE SMILES / InChI

Description

ITAMELINE, a tetrahydropyridine-oxime, is a long-lasting cholinomimetic agent. It is cleaved in vivo to form an active metabolite, RU 35963, a muscarinic receptor agonist that is nonselective with respect to receptor subtypes.

Originator

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Ameliorating effects of RU 47213, a novel oral and long-lasting cholinomimetic agent, on working memory impairments in rats.
1997-04
Name Type Language
RU-35963 free base
Preferred Name English
RU-35963
Code English
1,2,5,6-Tetrahydro-3-pyridinecarboxaldehyde O-methyloxime
Systematic Name English
RU35963
Code English
1-(4-chlorophenoxycarbonyl)-1,2,5, 6-tetrahydropyridine-3-carboxaldehyde-O-methyloxime
Systematic Name English
3-Pyridinecarboxaldehyde, 1,2,5,6-tetrahydro-, O-methyloxime, (E)-
Systematic Name English
3-Pyridinecarboxaldehyde, 1,2,5,6-tetrahydro-, O-methyloxime
Systematic Name English
Code System Code Type Description
CAS
139886-31-0
Created by admin on Wed Apr 02 19:48:35 GMT 2025 , Edited by admin on Wed Apr 02 19:48:35 GMT 2025
PRIMARY
PUBCHEM
9578336
Created by admin on Wed Apr 02 19:48:35 GMT 2025 , Edited by admin on Wed Apr 02 19:48:35 GMT 2025
PRIMARY
CAS
114485-41-5
Created by admin on Wed Apr 02 19:48:35 GMT 2025 , Edited by admin on Wed Apr 02 19:48:35 GMT 2025
NON-SPECIFIC STEREOCHEMISTRY
FDA UNII
SV4DB3E398
Created by admin on Wed Apr 02 19:48:35 GMT 2025 , Edited by admin on Wed Apr 02 19:48:35 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of RU-35963
PRODRUG (METABOLITE ACTIVE)
Structure of ITAMELINE
SALT/SOLVATE (PARENT)
Structure of RU-35963 hydrochloride
NIH
NCATS
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