ITAMELINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H15ClN2O3
Molecular Weight	294.734
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CO\N=C\C1=CCCN(C1)C(=O)OC2=CC=C(Cl)C=C2

InChI

InChIKey=CTVQNEVLCGSTKL-CXUHLZMHSA-N

InChI=1S/C14H15ClN2O3/c1-19-16-9-11-3-2-8-17(10-11)14(18)20-13-6-4-12(15)5-7-13/h3-7,9H,2,8,10H2,1H3/b16-9+

HIDE SMILES / InChI

Molecular Formula	C14H15ClN2O3
Molecular Weight	294.734
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9130292

ITAMELINE, a tetrahydropyridine-oxime, is a long-lasting cholinomimetic agent. It is cleaved in vivo to form an active metabolite, RU 35963, a muscarinic receptor agonist that is nonselective with respect to receptor subtypes.

Originator

Approval Year

PubMed

Title	Date	PubMed
Ameliorating effects of RU 47213, a novel oral and long-lasting cholinomimetic agent, on working memory impairments in rats.	1997-04	9130292

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:32:57 GMT 2025` Edited by `admin` on `Mon Mar 31 18:32:57 GMT 2025`
Record UNII	5VO597V509
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ITAMELINE

Official Name

English

RU-47213

Preferred Name

English

RU47213

Code

English

(E)-P-CHLOROPHENYL 3-FORMYL-5,6-DIHYDRO-1(2H)-PYRIDINECARBOXYLATE, O-METHYLOXIME

Common Name

English

itameline [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47796