U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 1401 - 1410 of 36617 results

Status:
Investigational
Source:
INN:dapabutan [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Dapabutan an antiseptic bacteriostatic drug, active against Gram-positive bacteria. Dapabutan is a component of a local antiseptic drug Sterlane.
Status:
Investigational
Source:
INN:danosteine
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Danosteine is an alkylthioacetic acid, developed by the French company Joullie International. The compound is claimed to have mucolytic action, demonstrated by inhibition of endobronchial retention of mucus induced by inhalation of SO2 in rats.
Status:
Investigational
Source:
INN:iolidonic acid
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Iolixanic Acid is triiodophenoxyalkoxyalkanoic acid derivative patented by Bracco Industria Chimica S.p.A. as diagnostic agent for cholecystography.
Status:
Investigational
Source:
INN:procodazole
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)


Procodazole is a non-specific active immunoprotective agent against viral and bacterial infections
Status:
Investigational
Source:
INN:ioseric acid
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Ioseric Acid is triiodoisophthalamic acid derivative patented by Schering A.-G. as x-ray contrast media
Status:
Investigational
Source:
INN:froxiprost
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Froxiprost (ONO-995), a synthetic analog of dinoprost, is a prostanoid receptor agonist. Froxiprost is active in contracting the uterine smooth muscle and is used as a pharmacological tool.
Status:
Investigational
Source:
INN:ibrolipim [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Lipoprotein lipase (LPL) is a rate-limiting enzyme that hydrolyzes circulating triglyceride-rich lipoproteins such as very low-density lipoproteins and chylomicrons. Otsuka Pharmaceutical Factory, Inc. synthesized the LPL activator NO-1886 (ibrolipim, [4-(4-bromo-2-cyano-phenylcarbamoyl)-benzyl]-phosphonic acid diethyl ester, CAS 133208-93-2). NO-1886 increased LPL mRNA and LPL activity in adipose tissue, myocardium and skeletal muscle, resulting in an elevation of postheparin plasma LPL activity and LPL mass. It was discovered, that this agent has a potentially beneficial for the treatment of hypertriglyceridemia, hypo-HDL cholesterolemia, and protection from atherosclerosis. In addition, this agent may be used in the treatment of obesity and obesity-linked health problems in postmenopausal women.
Status:
Investigational
Source:
INN:iotetric acid
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Iotetric Acid is triiodobenzoic acid derivative with potential application as neutrophil imaging in diagnosis of cystic fibrosis.
Status:
Investigational
Source:
INN:pirazmonam
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Pirazmonam is a potent anti-gram-negative monobactam that is differentiated from aztreonam by its high intrinsic activity against Ps. aeruginosa and good activity against Pseudomonas species. Pirazmonam has generally poor activity against gram-positive aerobic bacteria and anaerobic bacteria. Pirazmonam is a Trojan Horse molecule containing a b-lactam antibiotic that has been developed based on bacterial iron uptake systems. It features high structural similarity to aztreonam attached to a 3-hydroxy-4-pyridinone iron chelating group. Pirazmonam exhibited strong affinity to penicillin-binding protein 3 (PBP3) of Escherichia coli and moderate to negligible affinity to the other E. coli PBPs.
Status:
Investigational
Source:
INN:persilic acid [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Persilic acid is a virucide, hemostatic, capillary protective agent. 0.1% aqueous solution of K salt is used as a fluorescent acid-base indicator.

Showing 1401 - 1410 of 36617 results