FROXIPROST

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H29F3O6
Molecular Weight	470.4787
Optical Activity	UNSPECIFIED
Defined Stereocenters	5 / 5
E/Z Centers	3
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)\C=C\C\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)COC2=CC=CC(=C2)C(F)(F)F

InChI

InChIKey=REFZGTXXBBUTMJ-YDQNNXAVSA-N

InChI=1S/C24H29F3O6/c1-32-23(31)10-5-3-2-4-9-19-20(22(30)14-21(19)29)12-11-17(28)15-33-18-8-6-7-16(13-18)24(25,26)27/h2,4-8,10-13,17,19-22,28-30H,3,9,14-15H2,1H3/b4-2-,10-5+,12-11+/t17-,19-,20-,21+,22-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C24H29F3O6
Molecular Weight	470.4787
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	5 / 5
E/Z Centers	3
Optical Activity	UNSPECIFIED

Description
Sources: Morton I.K., Hall Judith M., Concise Dictionary of Pharmacological Agents: Properties and Synonyms, p. 126, retrieved from: https://books.google.ru/books?id=tsjrCAAAQBAJ&pg=PA126&lpg=PA126&dq=FROXIPROST&source=bl&ots=R4RxlIGqw5&sig=ACfU3U3fiodbXw9EeEQZH53PqQhnwgfuvQ&hl=ru&sa=X&ved=2ahUKEwj1zZCB_97jAhWitIsKHYyIDG84ChDoATABegQICRAB#v=onepage&q=FROXIPROST&f=false

Froxiprost (ONO-995), a synthetic analog of dinoprost, is a prostanoid receptor agonist. Froxiprost is active in contracting the uterine smooth muscle and is used as a pharmacological tool.

Approval Year

PubMed

Title	Date	PubMed
Involvement of phosphatidylcholine hydrolysis by phospholipase C in prostaglandin F2alpha-induced 1,2-diacylglycerol formation in osteoblast-like MC3T3-E1 cells.	2004	15108061

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:37:27 UTC 2023` Edited by `admin` on `Fri Dec 15 16:37:27 UTC 2023`
Record UNII	EOS1G6F668
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FROXIPROST

Official Name

English

froxiprost [INN]

Common Name

English

METHYL (2E,5Z)-7-((1R,2R,3R,5S)-3,5-DIHYDROXY-2-((E)-(3R)-3-HYDROXY-4-((.ALPHA.,.ALPHA.,.ALPHA.-TRIFLUORO-M-TOLYL)OXY)-1-BUTENYL)CYCLOPENTYL)-2,5-HEPTADIENOATE

Systematic Name

English

FROXIPROST [JAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78568