U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 131 - 140 of 152 results

Status:
Possibly Marketed Outside US
Source:
NCT03775876: Phase 4 Interventional Completed Hemodynamic
(2017)
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Tiamulin is a diterpene antimicrobial with a pleuromutilin chemical structure similar to that of valnemulin. The activity of tiamulin is largely confined to gram-positive micro-organisms and mycoplasma. Tiamulin acts by inhibiting protein synthesis at the ribosomal level. In veterinary medicine, tiamulin is used for treatment and prophylaxis of dysentery, pneumonia and mycoplasmal infections in pigs and poultry. Tiamulin is available as a 2, 10 or 20% premix for pigs and poultry, a 12.5% solution or 45% water soluble powder for addition to drinking water for pigs and poultry, or a 10% injectable formulation for pigs. Tiamulin inhibits protein synthesis by targeting the 50S bacterial ribosomal subunit and binding to peptidyl transferase, the enzyme responsible for forming peptide bonds between amino acids.
Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (RACEMIC)

Status:
Possibly Marketed Outside US

Class (Stereo):
CHEMICAL (ACHIRAL)

Monostearyl fumarate (sodium stearyl fumarate) is a lubricant for use in tablet formulation, it can be used as a taste-masking agent in orally disintegrating tablets. It is a conditioning and stabilizing agent.
Status:
Possibly Marketed Outside US
Source:
NCT00442962: Phase 4 Interventional Completed HIV Infections
(2007)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Maleic acid monosodium salt. Used in water soluble polymers preparation.
Status:
Possibly Marketed Outside US
Source:
NCT00442962: Phase 4 Interventional Completed HIV Infections
(2007)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Maleic acid monosodium salt. Used in water soluble polymers preparation.
Status:
Possibly Marketed Outside US
Source:
NCT03885778: Phase 4 Interventional Completed Food Effect
(2019)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

LB80380 is a prodrug of besifovir, a novel antiviral agent for the treatment of chronic hepatitis B.
Status:
Possibly Marketed Outside US
Source:
Japan:Zanapezil Fumarate
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Zanapezil (TAK-147) is a selective reversible acetylcholine (ACh) esterase inhibitor that was designed as a drug for Alzheimer's disease (AD) treatment. The development of the drug was discontinued due to a lack of a dose-dependent effect in the trials.
Status:
Possibly Marketed Outside US
Source:
NCT03300479: Phase 4 Interventional Withdrawn Nontraumatic Intracerebral Hemorrhage, Multiple Localized
(2017)
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)



Urapidil is an anti-hypertensive agent approved in Europe for the treatment of the corresponding disease. The drug acts by activating 5HT1a receptor and inhibiting alpha1-adrenergic receptors.

Showing 131 - 140 of 152 results