U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

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Showing 121 - 130 of 3547 results

Status:
Investigational
Source:
INN:resomelagon [INN]
Source URL:

Class (Stereo):
CHEMICAL (ACHIRAL)

Status:
Investigational
Source:
INN:gadoquatrane [INN]
Source URL:

Class (Stereo):
CHEMICAL (MIXED)

Status:
Investigational
Source:
INN:lefleuganan [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Status:
Investigational
Source:
INN:cormetasone
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Cormethasone is a topical antiinflammatory corticosteroid discovered by Du Pont.
Status:
Investigational
Source:
INN:talmetacin
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Talmetacin is a cyclo-oxygenase inhibitor that was studied as an analgesic and antipyretic agent. This drug was studied in Argentina in patients with rheumatic disorders. However, further development of talmetacin is not available.
Status:
Investigational
Source:
INN:sarsagenin [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)


PYM50018 (also known as Myogane or SARSAGENIN) has demonstrated neuroprotective effects in several preclinical models. It was observed that PYM50018 protects against neuronal damage, increases neurite outgrowth, reverses oxidative damage and reversed neuronal apoptosis. PYM50018 is in phase I clinical study for the treatment of amyotrophic lateral sclerosis (ALS).
Status:
Investigational
Source:
NCT00385307: Phase 3 Interventional Completed Major Depressive Disorder
(2006)
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)



Amibegron (SR 58611A or SR 58611) is a highly selective agonist for atypical beta3-adrenoceptors. It stimulates neuronal activity in a specific area of the prefrontal cortex and also inhibits intestinal motility. Amibegron was in phase III trials worldwide for the treatment of depression and generalised anxiety disorder but development of the product was discontinued in 2008. Amibegron has been tested for its potential as a treatment for irritable bowel syndrome.
Status:
Investigational
Source:
NCT01053962: Phase 2 Interventional Completed Chronic Idiopathic Constipation
(2010)
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Pirnabine is the synthetic dibenzopyran drug. It was developed as anti-glaucoma drug.
Status:
Investigational
Source:
INN:indorenate [INN]
Source URL:

Class (Stereo):
CHEMICAL (RACEMIC)

Indorenate (TR3369, INDO) is a serotonin-like compound with high affinity for 5- HT1A receptors and a lower affinity for 5-HT1C and 5-HT1B receptors. Indorenate possesses antihypertensive and anxiolytic activity in animal behaviour tests. Similar to other serotonin receptor agonists, Indorenate also has anorectic activity; this effect was blocked by the administration of the 5-HT2A/2C receptor antagonists cinanserin, cyproheptadine, metergoline and methysergide. A unpublished clinical trial confirmed its antihypertensive activity in men.
Status:
Investigational
Source:
INN:betacetylmethadol [INN]
Source URL:

Class (Stereo):
CHEMICAL (ABSOLUTE)

Betacetylmethadol is a synthetic narcotic analgesic under international control according to the UN Single Convention 1961.