SARSAGENIN

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C27H44O3
Molecular Weight	416.6365
Optical Activity	UNSPECIFIED
Defined Stereocenters	12 / 12
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

C[C@H]1[C@H]2[C@H](C[C@H]3[C@@H]4CC[C@@H]5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]23C)O[C@]16CC[C@H](C)CO6

InChI

InChIKey=GMBQZIIUCVWOCD-WWASVFFGSA-N

InChI=1S/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C27H44O3
Molecular Weight	416.6365
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	12 / 12
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: http://www.evaluategroup.com/Universal/View.aspx?type=Story&id=126822 | https://www.ncbi.nlm.nih.gov/pubmed/16118691

PYM50018 (also known as Myogane or SARSAGENIN) has demonstrated neuroprotective effects in several preclinical models. It was observed that PYM50018 protects against neuronal damage, increases neurite outgrowth, reverses oxidative damage and reversed neuronal apoptosis. PYM50018 is in phase I clinical study for the treatment of amyotrophic lateral sclerosis (ALS).

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Amyotrophic lateral sclerosis 39 Sources: http://www.evaluategroup.com/Universal/View.aspx?type=Story&id=126822	Primary		Phase I 438	Unknown Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
1PlusChem LLC	1P000R4T	https://www.1pchem.com/search?query=1P000R4T
AK Scientific	2770AC	https://aksci.com/item_detail.php?cat=2770AC
ApexBio Technology	N1451	https://www.apexbt.com/catalogsearch/result/?q=N1451
Apollo Scientific	BITH3027	http://www.apolloscientific.co.uk/chemical_results.php?qstext=BITH3027&product_group=%25&search_fieldname=header_search
AstaTech	42682	http://astatechinc.com/CPSResult.php?CRNO=42682
Biopurify Phytochemicals	BP1257	https://www.phytopurify.com/search.do?a=s&searchtype=3&psize=10&q=BP1257&searchhtmp=simplesearch&t=1
BLD Pharm	BD31681	http://www.bldpharm.com/search/Search.html?keyword=BD31681
BOC Sciences	126-19-2	http://www.bocsci.com/description.asp?cas=126-19-2
Chem Scene	CS-7949	http://www.chemscene.com/goproductList/searchProductList?productObj=CS-7949
ChemShuttle	159803	https://www.chemshuttle.com/catalogsearch/result/?q=159803
Combi-Blocks	QC-2039	http://www.combi-blocks.com/cgi-bin/find.cgi?QC-2039
eMolecules	29534537	https://orderbb.emolecules.com/search/#?query=29534537
eMolecules	36029168	https://orderbb.emolecules.com/search/#?query=36029168
eNovation Chemicals	D762266	https://www.enovationchem.com/Products.asp?SEARCHTEXT=D762266&searchbtn.x=0&searchbtn.y=0
Frontier Scientific Services	500054392	http://orders.frontierssi.com/fssionline32/public/product.aspx?cat=500054392&type=hts
Lab Seeker	SC-15309	http://www.labseeker.com/search.php?keywords=SC-15309&category=0
LabSeeker	SC-15309	http://www.labseeker.com/search.php?keywords=SC-15309&category=0
mcule	MCULE-3876651157	https://mcule.com/MCULE-3876651157/
MedChem Express	HY-N0073	https://www.medchemexpress.com/search.html?q=HY-N0073&ft=&fa=&fp=
Molnova	M11085	https://www.molnova.com/en/serch-list.html?keywords=M11085
MolPort	MolPort-005-932-869	https://www.molport.com/shop/molecule-link/MolPort-005-932-869
MuseChem	R034568	https://www.musechem.com/product/R034568.html
PI Chemicals	PI-40700	http://www.pipharm.com/catalog_products/PI-40700.html
Ryan Scientific	Forskolin	https://ryansci.com/products?q=Forskolin&list_q=&search_type=exact
TargetMol	BBP03823	https://www.targetmol.com/search?keyword=BBP03823
TargetMol	T2733	https://www.targetmol.com/search?keyword=T2733
Tetrahedron	TS81596	http://www.thsci.com/search.do?q=TS81596
Toronto Research Chemicals	S142505	https://www.trc-canada.com/product-detail/?CatNum=S142505

PubMed

Title	Date	PubMed
Natural Products in Drug Discovery and Development. 27-28 June 2005, London, UK.	2005-09	16118691

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:52:43 GMT 2025` Edited by `admin` on `Wed Apr 02 09:52:43 GMT 2025`
Record UNII	CFS802C28F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

SARSASAPOGENIN

Preferred Name

English

SARSAGENIN

Official Name

English

SARSASAPOGENIN [MI]

Common Name

English

sarsagenin [INN]

Common Name

English

(3.BETA.,5.BETA.,25S)-SPIROSTAN-3-OL

Systematic Name

English

PARIGENIN

Common Name

English

PURE SARSASAPOGENIN

Brand Name

English

NSC-1615

Code

English

SPIROSTAN-3-OL, (3.BETA.,5.BETA.,25S)-

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C823