U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C27H44O3
Molecular Weight 416.6365
Optical Activity UNSPECIFIED
Defined Stereocenters 12 / 12
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SARSAGENIN

SMILES

[H][C@]12C[C@@]3([H])[C@]4([H])CC[C@]5([H])C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3(C)[C@@]1([H])[C@H](C)[C@@]6(CC[C@H](C)CO6)O2

InChI

InChIKey=GMBQZIIUCVWOCD-WWASVFFGSA-N
InChI=1S/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1

HIDE SMILES / InChI
Molecular Formula C27H44O3
Molecular Weight 416.6365
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 11 / 12
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

PYM50018 (also known as Myogane or SARSAGENIN) has demonstrated neuroprotective effects in several preclinical models. It was observed that PYM50018 protects against neuronal damage, increases neurite outgrowth, reverses oxidative damage and reversed neuronal apoptosis. PYM50018 is in phase I clinical study for the treatment of amyotrophic lateral sclerosis (ALS).

Originator

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Phase I
428
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
1PlusChem LLC
1P000R4T
https://www.1pchem.com/search?query=1P000R4T
AK Scientific
2770AC
https://aksci.com/item_detail.php?cat=2770AC
ApexBio Technology
N1451
https://www.apexbt.com/catalogsearch/result/?q=N1451
Apollo Scientific
BITH3027
http://www.apolloscientific.co.uk/chemical_results.php?qstext=BITH3027&product_group=%25&search_fieldname=header_search
AstaTech
42682
http://astatechinc.com/CPSResult.php?CRNO=42682
BLD Pharm
BD31681
http://www.bldpharm.com/search/Search.html?keyword=BD31681
BOC Sciences
126-19-2
http://www.bocsci.com/description.asp?cas=126-19-2
Biopurify Phytochemicals
BP1257
https://www.phytopurify.com/search.do?a=s&searchtype=3&psize=10&q=BP1257&searchhtmp=simplesearch&t=1
Chem Scene
CS-7949
http://www.chemscene.com/goproductList/searchProductList?productObj=CS-7949
ChemShuttle
159803
https://www.chemshuttle.com/catalogsearch/result/?q=159803
Combi-Blocks
QC-2039
http://www.combi-blocks.com/cgi-bin/find.cgi?QC-2039
Frontier Scientific Services
500054392
http://orders.frontierssi.com/fssionline32/public/product.aspx?cat=500054392&type=hts
Lab Seeker
SC-15309
http://www.labseeker.com/search.php?keywords=SC-15309&category=0
LabSeeker
SC-15309
http://www.labseeker.com/search.php?keywords=SC-15309&category=0
MedChem Express
HY-N0073
https://www.medchemexpress.com/search.html?q=HY-N0073&ft=&fa=&fp=
MolPort
MolPort-005-932-869
https://www.molport.com/shop/molecule-link/MolPort-005-932-869
Molnova
M11085
https://www.molnova.com/en/serch-list.html?keywords=M11085
MuseChem
R034568
https://www.musechem.com/product/R034568.html
PI Chemicals
PI-40700
http://www.pipharm.com/catalog_products/PI-40700.html
Ryan Scientific
Forskolin
https://ryansci.com/products?q=Forskolin&list_q=&search_type=exact
TargetMol
BBP03823
https://www.targetmol.com/search?keyword=BBP03823
TargetMol
T2733
https://www.targetmol.com/search?keyword=T2733
Tetrahedron
TS81596
http://www.thsci.com/search.do?q=TS81596
Toronto Research Chemicals
S142505
https://www.trc-canada.com/product-detail/?CatNum=S142505
eMolecules
29534537
https://orderbb.emolecules.com/search/#?query=29534537
eMolecules
36029168
https://orderbb.emolecules.com/search/#?query=36029168
eNovation Chemicals
D762266
https://www.enovationchem.com/Products.asp?SEARCHTEXT=D762266&searchbtn.x=0&searchbtn.y=0
mcule
MCULE-3876651157
https://mcule.com/MCULE-3876651157/
PubMed

PubMed

TitleDatePubMed
Natural Products in Drug Discovery and Development. 27-28 June 2005, London, UK.
2005 Sep
Patents

Patents

WO2011026060A2
1

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 17:56:57 GMT 2023
Edited
by admin
on Sat Dec 16 17:56:57 GMT 2023
Record UNII
CFS802C28F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SARSAGENIN
INN  
INN  
Official Name English
SARSASAPOGENIN
INCI   MI  
INCI  
Official Name English
SARSASAPOGENIN [MI]
Common Name English
sarsagenin [INN]
Common Name English
(3.BETA.,5.BETA.,25S)-SPIROSTAN-3-OL
Systematic Name English
SARSASAPOGENIN [INCI]
Common Name English
PARIGENIN
Common Name English
PURE SARSASAPOGENIN
Brand Name English
NSC-1615
Code English
SPIROSTAN-3-OL, (3.BETA.,5.BETA.,25S)-
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C823
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
EU-Orphan Drug EU/3/08/543
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
FDA ORPHAN DRUG 185704
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
Code System Code Type Description
FDA UNII
CFS802C28F
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
PRIMARY
INN
9639
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
PRIMARY
NSC
1615
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
PRIMARY
MERCK INDEX
m9787
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
PRIMARY Merck Index
EPA CompTox
DTXSID00903921
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
PRIMARY
NCI_THESAURUS
C152305
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
PRIMARY
ECHA (EC/EINECS)
204-776-3
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
PRIMARY
CHEBI
15578
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
PRIMARY
CAS
126-19-2
Created by admin on Sat Dec 16 17:56:57 GMT 2023 , Edited by admin on Sat Dec 16 17:56:57 GMT 2023
PRIMARY
PUBCHEM
92095
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
PRIMARY
SMS_ID
100000177287
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
PRIMARY
WIKIPEDIA
SARSASAPOGENIN
Created by admin on Sat Dec 16 17:56:58 GMT 2023 , Edited by admin on Sat Dec 16 17:56:58 GMT 2023
PRIMARY
Related Record Type Details
Structure of SARSAGENIN
ACTIVE MOIETY
NIH
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