INDORENATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C13H16N2O3
Molecular Weight	248.2777
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC(=O)C(CN)C1=CNC2=CC=C(OC)C=C12

InChI

InChIKey=YFEDJMLMWJSRJJ-UHFFFAOYSA-N

InChI=1S/C13H16N2O3/c1-17-8-3-4-12-9(5-8)11(7-15-12)10(6-14)13(16)18-2/h3-5,7,10,15H,6,14H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C13H16N2O3
Molecular Weight	248.2777
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/12479957 | https://www.ncbi.nlm.nih.gov/pubmed/12474119 | https://www.ncbi.nlm.nih.gov/pubmed/11277605

Indorenate (TR3369, INDO) is a serotonin-like compound with high affinity for 5- HT1A receptors and a lower affinity for 5-HT1C and 5-HT1B receptors. Indorenate possesses antihypertensive and anxiolytic activity in animal behaviour tests. Similar to other serotonin receptor agonists, Indorenate also has anorectic activity; this effect was blocked by the administration of the 5-HT2A/2C receptor antagonists cinanserin, cyproheptadine, metergoline and methysergide. A unpublished clinical trial confirmed its antihypertensive activity in men.

Originator

Approval Year

PubMed

Title	Date	PubMed
Discriminative stimulus properties of indorenate, a 5-HT1A, 5-HT1B and 5-HT2C agonist: a study in rats.	2001 Mar	11277605

Patents

Sample Use Guides

In Vivo Use Guide

rats: 1, 3, 10 mg/kg, i.p.

Route of Administration: Intraperitoneal

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:51:10 GMT 2023` Edited by `admin` on `Sat Dec 16 17:51:10 GMT 2023`
Record UNII	AV9L041QA4
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

INDORENATE

Official Name

English

1H-INDOLE-3-ACETIC ACID, .ALPHA.-(AMINOMETHYL)-5-METHOXY-, METHYL ESTER

Common Name

English

METHYL (±)-.ALPHA.-(AMINOMETHYL)-5-METHOXYINDOLE-3-ACETATE

Systematic Name

English

indorenate [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C47794