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Restrict the search for
icosapent ethyl
to a specific field?
Status:
Investigational
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Etoxadrol is an NMDA receptor antagonist. It exerts phencyclidine-like properties. Etoxadrol has anticonvulsant and anesthetic activity. Intravenous etoxadrol was clinically tested as an anesthetic.
Status:
Investigational
Source:
NCT02211872: Phase 1 Interventional Completed Neoplasms
(2004)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
BI-2536, an inhibitor of Polo-like kinase 1 (Plk-1) was being investigated by Boehringer Ingelheim as a possible treatment for cancer. BI-2536 inhibits Plk1 enzyme activity at low nanomolar concentrations. The compound potently causes a mitotic arrest and induces apoptosis in human cancer cell lines of diverse tissue origin and oncogenome signature. BI-2536 inhibits growth of human tumor xenografts in nude mice and induces regression of large tumors with well-tolerated intravenous dose regimens. In treated tumors, cells arrest in prometaphase, accumulate phosphohistone H3, and contain aberrant mitotic spindles. This mitotic arrest is followed by a surge in apoptosis, detectable by immunohistochemistry and noninvasive optical and magnetic resonance imaging. For addressing the therapeutic potential of Plk1 inhibition, BI-2536 has progressed into clinical studies in patients with locally advanced or metastatic cancers. It underwent phase II clinical studies for the treatment of breast cancer; non-small cell lung cancer; pancreatic cancer; prostate cancer; small cell lung cancer, but these studies were discontinued later.
Class (Stereo):
CHEMICAL (ACHIRAL)
Carperidine is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine. Carperidine is not currently used in medicine. Presumably it has similar effects to other opioid derivatives, such as analgesia, sedation, nausea and respiratory depression, however unlike most opioid derivatives it is not specifically listed as an illegal drug, although it is on the drugs and poisons lists of some countries, and would probably be regarded as a controlled substance analogue of pethidine on the grounds of its related chemical structure in some jurisdictions such as the USA, Canada, Australia and New Zealand.
Status:
Investigational
Class (Stereo):
CHEMICAL (MIXED)
Capuride is a a central nervous systemactive urea derivative of valnoctic acid patented by pharmaceutical company Abbott Laboratories as sedative therapeutic compound with a duration of hypnotic effect similar to that of the short‐acting barbiturates.
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Quazodine (also known as MJ-1988) is a quinazoline derivative patented by Fujisawa Pharmaceutical Co. as a muscle relaxant. In cats anesthetized with sodium pentobarbitone. Quazodine decreased diastolic blood pressure, peripheral vascular resistance, systolic ejection time and left ventricular end-diastolic pressure in cats. Heart rate, cardiac effort, output, and external work and left ventricular dP/dt were markedly increased. In the intact dog, as well as in the heart-lung preparation., the stimulant action on the force of myocardial contraction was accompanied by increases in coronary blood flow, pulmonary vasodilation, and bronchodilation. Administration of larger doses caused depression of cardiac function and initiated cardiac arrhythmias.
Status:
Investigational
Source:
INN:cartazolate [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Cartazolate (also known as SQ-65,396) is GABAA receptor positive allosteric modulator with potent anxiolytic activity proven in clinical trials. Cartazolate is also known to act as an adenosine antagonist at the A1 and A2 subtypes and as a phosphodiesterase inhibitor.
Class (Stereo):
CHEMICAL (ACHIRAL)
Oxagrelate (also known as EG626) is an inhibitor of cAMP phosphodiesterase and lead to the platelet aggregation inhibition. Oxagrelate was studied as a smooth muscle relaxant. Information about the further development of this drug is not available.
Status:
Investigational
Source:
INN:triflumidate [INN]
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Triflumidate is a fluoroalkanesulfonanilide. It had been identified for clinical trials. This non-steroidal compound is an anti-inflammatory agent.
Status:
Class (Stereo):
CHEMICAL (ACHIRAL)
Probarbital is ethylisopropylbarbituric acid patented by Thorp, L as hypnotic and sedative agent.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Toquizine is an anticholinergic agent. It was used as an antiulcer agent.
