A-582941 was found to exhibit high-affinity binding and agonism at alpha-7 nicotinic acetylcholine receptor (α7-nAChR), with acceptable pharmacokinetic properties and excellent distribution to the central nervous system. In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation. A-582941 enhanced cognitive performance in behavioral assays including the monkey delayed matching-to-sample, rat social recognition, and mouse inhibitory avoidance models that capture domains of working memory, short-term recognition memory, and long-term memory consolidation, respectively. AbbVie is developing α7-nAChR agonists including A-582941 as neuroprotective agents for the treatment of cognitive disorders such as Alzheimer's disease and schizophrenia. Development is at the preclinical stage.

A DNA stain used as a tracking dye in acid buffers for electrophoresis. Methyl Green was used as a topical antiseptic, however, it was withdrawn due to unwanted effects. The traditional Methyl Green has not manufactured for decades. The dye sold as Methyl Green is more accurately described as Ethyl Green. Both, Methyl Green and Ethyl Green are sold as double zinc salts.