METHYL GREEN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H33N3.2Cl
Molecular Weight	458.466
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].[Cl-].CN(C)C1=CC=C(C=C1)C(C2=CC=C(C=C2)[N+](C)(C)C)=C3C=CC(C=C3)=[N+](C)C

InChI

InChIKey=DWCZIOOZPIDHAB-UHFFFAOYSA-L

InChI=1S/C26H33N3.2ClH/c1-27(2)23-14-8-20(9-15-23)26(21-10-16-24(17-11-21)28(3)4)22-12-18-25(19-13-22)29(5,6)7;;/h8-19H,1-7H3;2*1H/q+2;;/p-2

HIDE SMILES / InChI

Description
Sources: DOI: 10.1201/9780849382192.ch11, Sabnis R.W., 'Handbook of Acid-Base Indicators' (2007), p. 149

A DNA stain used as a tracking dye in acid buffers for electrophoresis. Methyl Green was used as a topical antiseptic, however, it was withdrawn due to unwanted effects. The traditional Methyl Green has not manufactured for decades. The dye sold as Methyl Green is more accurately described as Ethyl Green. Both, Methyl Green and Ethyl Green are sold as double zinc salts.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Skin infections 59 Sources: De Groot A., Nater J.P., Weyland W. (1994) Unwanted Effects of Cosmetics and Drugs Used in Dermatology, page 267, retrieved from https://books.google.com/books?id=Ud0jOl-8eG4C&	Curative		Withdrawn	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
The Nature of the Specificity of Methyl Green for Chromatin.	1949 Feb	16588861
Spectrophotometry of dyes. I. Methyl green. II. Pyronin.	1953 Nov	13113451
On the nature of the deoxyribonucleic acid-methyl green reaction.	1958 Sep 25	13587564

Patents

Sample Use Guides

In Vivo Use Guide

1% solution is applied to the affected area.

Route of Administration: Topical

In Vitro Use Guide

Methyl green inhibited B.aerogenis, B.coli, B.typhosus, with the inhibiting dilution of 1200 and B.proteus with he inhibiting dilution of 2700.

Name

Type

Language

METHYL GREEN

Common Name

English

BASIC BLUE 20

Common Name

English

DOUBLE GREEN

Common Name

English

AMMONIUM, (.ALPHA.-(P-(DIMETHYLAMINO)PHENYL)-.ALPHA.-(4- (DIMETHYLIMINIO)-2,5-CYCLOHEXADIEN-1-YLIDENE)-P- TOLYL)TRIMETHYL-, DICHLORIDE

Systematic Name

English

C.I. BASIC VIOLET 3, COMPD. WITH CHLOROMETHANE (1:1)

Common Name

English

BENZENAMINIUM, 4-((4-(DIMETHYLAMINO)PHENYL)(4- (DIMETHYLIMINIO)-2,5-CYCLOHEXADIEN-1-YLIDENE)METHYL)-N,N,N- TRIMETHYL-, CHLORIDE (1:2)

Systematic Name

English

C.I. BASIC BLUE 20

Common Name

English

4-((4-(DIMETHYLAMINO)PHENYL)(4-(DIMETHYLIMINIO)CYCLOHEXA- 2,5-DIEN-1-YLIDENE)METHYL)-N,N,N-TRIMETHYLANILINIUM DICHLORIDE

Systematic Name

English

BENZENAMINIUM, 4-((4-(DIMETHYLAMINO)PHENYL)(4- (DIMETHYLIMINIO)-2,5-CYCLOHEXADIEN-1-YLIDENE)METHYL)-N,N,N- TRIMETHYL-, DICHLORIDE

Systematic Name

English

Code System Code Type Description

FDA UNII

6P7U4T9BXA