METHYL GREEN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C26H33N3.2Cl
Molecular Weight	458.466
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cl-].[Cl-].CN(C)C1=CC=C(C=C1)C(C2=CC=C(C=C2)[N+](C)(C)C)=C3C=CC(C=C3)=[N+](C)C

InChI

InChIKey=DWCZIOOZPIDHAB-UHFFFAOYSA-L

InChI=1S/C26H33N3.2ClH/c1-27(2)23-14-8-20(9-15-23)26(21-10-16-24(17-11-21)28(3)4)22-12-18-25(19-13-22)29(5,6)7;;/h8-19H,1-7H3;2*1H/q+2;;/p-2

HIDE SMILES / InChI

Molecular Formula	Cl
Molecular Weight	35.453
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C26H33N3
Molecular Weight	387.5603
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: DOI: 10.1201/9780849382192.ch11, Sabnis R.W., 'Handbook of Acid-Base Indicators' (2007), p. 149

A DNA stain used as a tracking dye in acid buffers for electrophoresis. Methyl Green was used as a topical antiseptic, however, it was withdrawn due to unwanted effects. The traditional Methyl Green has not manufactured for decades. The dye sold as Methyl Green is more accurately described as Ethyl Green. Both, Methyl Green and Ethyl Green are sold as double zinc salts.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Skin infections 59 Sources: De Groot A., Nater J.P., Weyland W. (1994) Unwanted Effects of Cosmetics and Drugs Used in Dermatology, page 267, retrieved from https://books.google.com/books?id=Ud0jOl-8eG4C&	Curative		Withdrawn	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Methyl green. III. Reaction with desoxyribonucleic acid, stoichiometry, and behavior of the reaction product.	1950 Nov	14824487
On the nature of the deoxyribonucleic acid-methyl green reaction.	1958 Sep 25	13587564
Methyl green-pyronin stain for the diagnosis of trachoma.	1969 Apr	4181057

Patents

Sample Use Guides

In Vivo Use Guide

1% solution is applied to the affected area.

Route of Administration: Topical

In Vitro Use Guide

Methyl green inhibited B.aerogenis, B.coli, B.typhosus, with the inhibiting dilution of 1200 and B.proteus with he inhibiting dilution of 2700.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:39:50 GMT 2023` Edited by `admin` on `Sat Dec 16 09:39:50 GMT 2023`
Record UNII	6P7U4T9BXA
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

METHYL GREEN

Common Name

English

BASIC BLUE 20

Common Name

English

DOUBLE GREEN

Common Name

English

AMMONIUM, (.ALPHA.-(P-(DIMETHYLAMINO)PHENYL)-.ALPHA.-(4- (DIMETHYLIMINIO)-2,5-CYCLOHEXADIEN-1-YLIDENE)-P- TOLYL)TRIMETHYL-, DICHLORIDE

Systematic Name

English

C.I. BASIC VIOLET 3, COMPD. WITH CHLOROMETHANE (1:1)

Common Name

English

BENZENAMINIUM, 4-((4-(DIMETHYLAMINO)PHENYL)(4- (DIMETHYLIMINIO)-2,5-CYCLOHEXADIEN-1-YLIDENE)METHYL)-N,N,N- TRIMETHYL-, CHLORIDE (1:2)

Systematic Name

English

C.I. BASIC BLUE 20

Common Name

English

4-((4-(DIMETHYLAMINO)PHENYL)(4-(DIMETHYLIMINIO)CYCLOHEXA- 2,5-DIEN-1-YLIDENE)METHYL)-N,N,N-TRIMETHYLANILINIUM DICHLORIDE

Systematic Name

English

BENZENAMINIUM, 4-((4-(DIMETHYLAMINO)PHENYL)(4- (DIMETHYLIMINIO)-2,5-CYCLOHEXADIEN-1-YLIDENE)METHYL)-N,N,N- TRIMETHYL-, DICHLORIDE

Systematic Name

English

Code System Code Type Description

FDA UNII

6P7U4T9BXA