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Restrict the search for
estramustine phosphate
to a specific field?
Status:
Possibly Marketed Outside US
Source:
NDA210134
(1960)
Source URL:
First approved in 1960
Source:
NDA210134
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Status:
Possibly Marketed Outside US
Source:
Azaserine
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
A naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized. An antibiotic and antitumor agent, Azaserine was used in clinical studies as a potential antineoplastic agent. Azaserine is an inhibitor of glutamine: fructose-6-phosphate amidotransferase (GFAT), which is the rate-limiting enzyme in the hexosamine biosynthetic pathway. Azaserine is used to model pancreatic cancer in rodents.
Status:
Possibly Marketed Outside US
Source:
Atgard by Montrose Chemical
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Dichlorvos is a synthetic organic chemical used as an insecticide. Dichlorvos does not occur naturally in the environment, but is manufactured by industry. Dichlorvos is sold under many trade names including Vapona®, Atgard®, Nuvan®, and Task®. It is also used as
an insecticide for slow release on pest-strips for pest control in homes. Dichlorvos is used as an
anthelmintic (worming agent) for dogs, swine, and horses, as a botacide (agent that kills fly larvae) for
horses, and in flea collars for dogs. In 1995, EPA proposed cancellation of dichlorvos for all home uses, and for many commercial and
industrial uses.
Status:
Possibly Marketed Outside US
Source:
NCT04359615: Phase 4 Interventional Unknown status COVID-19
(2020)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Favipiravir (originally known as T-705) is an orally administered novel anti-viral compound with a unique mechanism of action that is active against a wide range of RNA-based viruses in laboratory tests. Favipiravir has recently being approved in Japan under the brand name Avigan. Avigan is an experimental antiviral drug being developed by Toyama Chemical of Japan. It is a viral RNA polymerase inhibitor with a new mechanism of action, inhibiting viral gene replication within infected cells to prevent the propagation. Favipiravir is
phosphoribosylated by cellular enzymes to its active form, favipiravir-ribofuranosyl-5′- triphosphate (RTP). Favipiravir is active against a broad range of influenza viruses, including
A(H1N1)pdm09, A(H5N1) and the recently emerged A(H7N9) avian virus. It also inhibits
influenza strains resistant to current antiviral drugs, and shows a synergistic effect in combination
with oseltamivir, thereby expanding influenza treatment options. A Phase III clinical evaluation of
favipiravir for influenza therapy has been completed in Japan and two Phase II studies have been
completed in the United States. In addition to its anti-influenza activity, favipiravir blocks the
replication of many other RNA viruses, including arenaviruses (Junin, Machupo and Pichinde);
phleboviruses (Rift Valley fever, sandfly fever and Punta Toro); hantaviruses (Maporal, Dobrava,
and Prospect Hill); flaviviruses (yellow fever and West Nile); enteroviruses (polio- and
rhinoviruses); an alphavirus, Western equine encephalitis virus; a paramyxovirus, respiratory
syncytial virus; and noroviruses.
Status:
Possibly Marketed Outside US
Source:
Butanilicaine by Enreco, INC
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Butanilicaine (Hostacain) is a local anesthetic. It uses may associate with a risk of allergy. Butanilicaine has a vasodilator effect.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
TAT-59 (Miproxifene Phosphate) is a triphenylethylene analog of tamoxifen. TAT-59 is the phosphate ester prodrug of the practically insoluble parent drug DP-TAT-59. It is an antiestrogen developed in Japan for breast cancer. It is a potent antitumor agent for hormone-dependent tumors. Most of TAT-59 metabolites possessed remarkable binding affinity toward estrogenic receptors as well as fairly good antiuterotrophic activity.
Status:
Possibly Marketed Outside US
Class (Stereo):
CHEMICAL (ABSOLUTE)
Status:
Possibly Marketed Outside US
Source:
NCT00892892: Phase 4 Interventional Withdrawn Chronic Kidney Disease
(2009)
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Rilmenidine (brand names Albarel, Hyperium, Iterium and Tenaxum) is an imidazoline derivative used for the treatment of hypertension. Rilmenidine, an oxazoline compound with antihypertensive properties, acts on both medullary and peripheral vasomotor structures. Rilmenidine shows greater selectivity for imidazoline receptors than for cerebral alpha2-adrenergic receptors, distinguishing it from reference alpha2-agonists. Rilmenidine is as effective in monotherapy as all other first line classes of drugs, including diuretics, beta-blockers, angiotensin converting enzyme (ACE) inhibitors, and calcium antagonists. It is well tolerated and can be taken in combination for greater efficacy. Sedation and dry mouth are not prominent side effects and withdrawal hypertension is not seen when treatment is stopped abruptly. In addition to a reduction in blood pressure, Rilmenidine has been shown to improve glucose tolerance, lipid risk factors, and insulin sensitivity.
Status:
Possibly Marketed Outside US
Source:
NCT02213068: Phase 4 Interventional Completed Transplant; Failure, Kidney
(2014)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Aminopropyl racementhyl phosphate is a prodrug of menthol patented by Pacific Corporation (Korea). Upon administration, it is enzymatically decomposed into menthol and 3-aminopropylphosphoric acid, a component used for anti-aging cosmetic composition. Aminopropyl racementhyl phosphate was found to reduce the irritation of menthol while maintaining its useful effects.
Status:
Possibly Marketed Outside US
Source:
Starasid by Nippon Kayaku|Yamasa
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Conditions:
Cytarabine ocfosfate (commercial name: Starasid) is a prodrug having stearyl group attached to phosphoric acid at 5' position of arabinose moiety of cytosine arabinoside (Ara-C). This drug is given orally. The mode of action is in the inhibition of DNA synthesis after conversion to Ara-CTP as in Ara-C. The drug is metabolized in the liver, producing the intermediate metabolite, C-C3PCA which is converted to Ara-C gradually. This property results in the maintenance of relatively long time the blood Ara-C levels. This was proved to be active clinically against acute leukemia and MDS.
