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Restrict the search for
dimethyl fumarate
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Status:
US Previously Marketed
Source:
ALLONAL AMINOPHENAZONE by ROCHE
(1961)
Source URL:
First marketed in 1897
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Aminophenazone is a phenyl-pyrazolone derivative with potent analgesic and antipyretic properties. Aminophenazone has been used as salt or complexes, including topically as the salicylate. It was recommended for the treatment of a fever, neuralgia, myositis, acute rheumatism, arthritis, chorea. In 1999 the FDA suspended aminophenazone. The drug caused agranulocytosis. Some of the cases of agranulocytosis were fatal. Another reason for suspending this drug from the market was its ability to react with nitrite-containing food, thus forming carcinogenic nitrosamines. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests.
Status:
US Previously Marketed
Source:
ALLONAL AMINOPHENAZONE by ROCHE
(1961)
Source URL:
First marketed in 1897
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Aminophenazone is a phenyl-pyrazolone derivative with potent analgesic and antipyretic properties. Aminophenazone has been used as salt or complexes, including topically as the salicylate. It was recommended for the treatment of a fever, neuralgia, myositis, acute rheumatism, arthritis, chorea. In 1999 the FDA suspended aminophenazone. The drug caused agranulocytosis. Some of the cases of agranulocytosis were fatal. Another reason for suspending this drug from the market was its ability to react with nitrite-containing food, thus forming carcinogenic nitrosamines. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests.
Status:
US Previously Marketed
Source:
ALLONAL AMINOPHENAZONE by ROCHE
(1961)
Source URL:
First marketed in 1897
Class (Stereo):
CHEMICAL (ABSOLUTE)
Targets:
Conditions:
Aminophenazone is a phenyl-pyrazolone derivative with potent analgesic and antipyretic properties. Aminophenazone has been used as salt or complexes, including topically as the salicylate. It was recommended for the treatment of a fever, neuralgia, myositis, acute rheumatism, arthritis, chorea. In 1999 the FDA suspended aminophenazone. The drug caused agranulocytosis. Some of the cases of agranulocytosis were fatal. Another reason for suspending this drug from the market was its ability to react with nitrite-containing food, thus forming carcinogenic nitrosamines. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests.
Status:
US Previously Marketed
Source:
ALLONAL AMINOPHENAZONE by ROCHE
(1961)
Source URL:
First marketed in 1897
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Aminophenazone is a phenyl-pyrazolone derivative with potent analgesic and antipyretic properties. Aminophenazone has been used as salt or complexes, including topically as the salicylate. It was recommended for the treatment of a fever, neuralgia, myositis, acute rheumatism, arthritis, chorea. In 1999 the FDA suspended aminophenazone. The drug caused agranulocytosis. Some of the cases of agranulocytosis were fatal. Another reason for suspending this drug from the market was its ability to react with nitrite-containing food, thus forming carcinogenic nitrosamines. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests.
Status:
US Previously Marketed
Source:
ALLONAL AMINOPHENAZONE by ROCHE
(1961)
Source URL:
First marketed in 1897
Class (Stereo):
CHEMICAL (ACHIRAL)
Targets:
Conditions:
Aminophenazone is a phenyl-pyrazolone derivative with potent analgesic and antipyretic properties. Aminophenazone has been used as salt or complexes, including topically as the salicylate. It was recommended for the treatment of a fever, neuralgia, myositis, acute rheumatism, arthritis, chorea. In 1999 the FDA suspended aminophenazone. The drug caused agranulocytosis. Some of the cases of agranulocytosis were fatal. Another reason for suspending this drug from the market was its ability to react with nitrite-containing food, thus forming carcinogenic nitrosamines. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests.
Status:
US Previously Marketed
Source:
ALLONAL AMINOPHENAZONE by ROCHE
(1961)
Source URL:
First marketed in 1897
Class (Stereo):
CHEMICAL (RACEMIC)
Targets:
Conditions:
Aminophenazone is a phenyl-pyrazolone derivative with potent analgesic and antipyretic properties. Aminophenazone has been used as salt or complexes, including topically as the salicylate. It was recommended for the treatment of a fever, neuralgia, myositis, acute rheumatism, arthritis, chorea. In 1999 the FDA suspended aminophenazone. The drug caused agranulocytosis. Some of the cases of agranulocytosis were fatal. Another reason for suspending this drug from the market was its ability to react with nitrite-containing food, thus forming carcinogenic nitrosamines. A breath test with 13C-labeled aminopyrine has been used as a non-invasive measure of cytochrome P-450 metabolic activity in liver function tests.
Status:
US Previously Marketed
First marketed in 1885
Class (Stereo):
CHEMICAL (RACEMIC)
Conditions:
Antipyrine is an analgesic and antipyretic that has been given by mouth and as ear drops. It is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. It inhibits cyclooxygenases and shows little anti-inflammatory activity. Like many old and approved substances after almost 100 years of use, antipyrine has been associated with some serious side effects, namely agranulocytosis and shock reactions.
Status:
US Previously Marketed
Source:
64 FR 27682 sunscreen sodium 3, 4-dimethylphenyl-glyoxylate
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
Sodium 3,4-dimethylphenylglyoxylate is a topical analgesic, sunscreen ingredient, UV-B absorber, FDA approved.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(6)(i) cough/cold:antihistamine thenyldiamine hydrochloride
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
There is not much available information about thenyldiamine, is known, that it is used as antihistamine and for the treatment of asthma and bronchitis.
Status:
US Previously Marketed
Source:
21 CFR 310.545(a)(6)(i) cough/cold:antihistamine thenyldiamine hydrochloride
Source URL:
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
There is not much available information about thenyldiamine, is known, that it is used as antihistamine and for the treatment of asthma and bronchitis.
