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Restrict the search for
icosapent ethyl
to a specific field?
Status:
Investigational
Class (Stereo):
CHEMICAL (ACHIRAL)
Befiperide, a non-dopaminolytic serotonin 1 receptor agonist, was a neuroleptic for psychotic disorders. However, further studies for this drug were discontinued.
Class (Stereo):
CHEMICAL (ACHIRAL)
Clobenzepam (tarpane) is a drug exhibiting antihistaminic properties.
Status:
Investigational
Source:
INN:clobenoside [INN]
Source URL:
Class (Stereo):
CHEMICAL (EPIMERIC)
Clobenoside is a vasoprotective and anti-inflammatory agent. The drug was used for the topical treatment of chronic venous insufficiency and post-thrombotic syndrome. Clobenoside was also reportedly effective in treating traumatic edema through its inhibitory effects on histamine and/or kinins.
Class (Stereo):
CHEMICAL (ACHIRAL)
Conditions:
There is no information about biological and medical application of dorastine . It’s known, that compound possesses antihistamine properties and can be obtained from 4-chloroaniline.
Status:
Investigational
Source:
USAN:BESONPRODIL [USAN]
Source URL:
Class (Stereo):
CHEMICAL (UNKNOWN)
Besonprodil (also known as CI-1041), an NR2B subunit specific NMDA receptor antagonist, has been developed for the treatment of certain inflammatory and neuropathic pain, however, these studies were discontinued. Besides, besonprodil was investigated as a supplemental medication for Parkinson's disease. Experiments on animals have shown that this drug could be effective in counteracting the dyskinesia associated with long-term treatment with levodopa and related drugs.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Siratiazem [LRA 113] is a calcium channel antagonist that is structurally similar to diltiazem but has a branched alkyl group on the basic nitrogen. Siratiazem has been developed in an attempt to limit the in vivo N-demethylation that is known to occur with diltiazem. Preliminary binding and functional studies in cardiac and vascular tissues indicate that it not only binds to diltiazem binding sites but also exhibits Ca2+ channel blocking
properties comparable to diltiazem. Siratiazem has a similar profile of activity to its parent compound, diltiazem, in that it blocks calcium channels in vascular, intestinal smooth muscle and cardiac tissue, and is least potent in cardiac muscle. At higher concentrations, siratiazem may also block cardiac sodium channels.
Status:
Investigational
Source:
NCT02569827: Phase 1/Phase 2 Interventional Withdrawn Dengue Fever
(2018)
Source URL:
Class (Stereo):
CHEMICAL (ABSOLUTE)
Modipafant is a dihydropyridine derivative patented by American multinational pharmaceutical corporation Pfizer Ltd. as platelet-activating factor antagonist for bronchoconstriction and asthma treatment. Platelet-activating factor, proposed as an important inflammatory mediator in asthma, reproduces several of the features of asthma, such as microvascular leakage, mucus secretion, bronchoconstriction, and possibly increased airway responsiveness. Unfortunately, in clinical trials, Modipafant failed to demonstrate superior efficacy compared to placebo.
Class (Stereo):
CHEMICAL (ACHIRAL)
Piroxantrone is one of a series of compounds commonly known as anthrapyrazoles developed in an effort to combine the broad antitumor activity of the anthracyclines with decreased myocardial toxicity. The mechanism of action of piroxantrone and other anthrapyrazoles is incompletely understood but likely involves DNA binding with induction of DNA strand breaks, DNA-protein cross-linking, and inhibition of DNA, RNA, and protein synthesis. Collectively, these findings suggested an interaction with topoisomerase II. Piroxantrone demonstrated antitumor activity in a wide spectrum of experimental systems against breast carcinoma, colon carcinoma, sarcoma, melanoma and leukemia. Piroxantrone is inactive in patients with persistent, progressive, or recurrent ovarian cancer who recently had received a platinum-based regimen. Piroxantrone has detectable but minimal activity against disseminated malignant melanoma. A phase II clinical trial of the piroxantrone administration for the treatment of advanced metastatic or recurrent endometrial cancer was prematurely terminated due to lack of patient accrual.
Class (Stereo):
CHEMICAL (ABSOLUTE)
Ambamustine (PTT-119) is a bifunctional alkylating agent. Its antitumour effect is reported to mainly be through alkylation and interstrand cross-linkage of DNA. The drug was awaiting registration in Italy for the treatment of non-Hodgkin's lymphoma, and was also in phase-II clinical trial for small cell lung cancer, but was discontinued.
Class (Stereo):
CHEMICAL (RACEMIC)
Quincarbate is a quinoline derivative patented by N. V. Philips' Gloeilampenfabrieken as diuretic. At 12.5 mg/kg orally in rats Quincarbate increased urine excretion by 130%.
