Jervine (11-Ketocyclopamine) is a naturally occuring steroidal alkaloid is derived from the Veratrum plant species. Jervine is a teratogen implicated in birth defects when consumed by animals during a certain period of their gestation. Over the Hedgehog signaling pathway Jervine effectively inhibit the tumor growth using three human tumor xenograft models including lung cancer, pancreatic cancer and basal cell carcinoma. Jervine has the potential to advance to a treatment for different tumors.

Saponarin (SA), a natural flavonoid, is known for its antioxidant and hepatoprotective activities. Saponarin is found in diverse plants, including Tinospora cordifolia, which is used in an anti-diabetic drug, Aloe barbadensis, and barley leaves.Saponarin, isolated from Gypsophila trichotoma Wend., showed in vitro and in vivo hepatoprotective and antioxidant activity against CCl₄-induced liver damage. Saponarin pretreatment also decreased cocaine toxicity both by increasing GSH levels and antioxidant enzyme activities. SA isolated from barley sprouts exerts anti-inflammatory effects in LPS-induced RAW 264.7 macrophages via inhibition of NF-κB, ERK and p38 signaling. Thus, SA may be a promising natural anti-inflammatory agent. Saponarin improves gluconeogenesis and glucose uptake. Saponarin regulates AMPK through induction of intracellular calcium levels. Saponarin has a hypoglycemic effect through the activation of the AMMKb–AMPK–CREB signaling axis in hepatocytes.